标准化肌酐与胱抑素C比值与中老年人心脏代谢多病的风险:来自中国健康与退休纵向研究的见解

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2025-05-01 Epub Date: 2025-01-20 DOI:10.4093/dmj.2024.0100
Honglin Sun, Zhenyu Wu, Guang Wang, Jia Liu
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引用次数: 0

摘要

背景:据报道,标准化肌酐与胱抑素C比值(NCCR)近似于相对骨骼肌质量和糖尿病风险。然而,NCCR与心脏代谢多病(CMM)之间的关系仍然难以捉摸。本研究旨在通过大规模前瞻性队列来探讨两者之间的关系。方法:本研究纳入了2011 - 2012年中国健康与退休纵向研究(CHARLS)的5849名中老年参与者。基线NCCR确定为肌酐(mg/dL)/胱抑素C (mg/L)×10/体重(kg)。CMM被定义为同时出现以下两种或两种以上疾病:心脏病、中风和2型糖尿病。采用Logistic回归分析和Cox回归分析估计NCCR与CMM之间的关系。进一步分析体重指数和NCCR对CMM发生风险的共同影响。结果:在中位4年随访期间,227名(3.9%)参与者发展为CMM。随着NCCR的每标准差增加,CMM的风险显著降低(优势比,0.72;95%可信区间,0.62 - 0.85)。结论:高NCCR与中国中老年人(尤其是女性)CMM风险降低独立相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Normalized Creatinine-to-Cystatin C Ratio and Risk of Cardiometabolic Multimorbidity in Middle-Aged and Older Adults: Insights from the China Health and Retirement Longitudinal Study.

Backgruound: Normalized creatinine-to-cystatin C ratio (NCCR) was reported to approximate relative skeletal muscle mass and diabetes risk. However, the association between NCCR and cardiometabolic multimorbidity (CMM) remains elusive. This study aimed to explore their relationship in a large-scale prospective cohort.

Methods: This study included 5,849 middle-age and older participants from the China Health and Retirement Longitudinal Study (CHARLS) enrolled between 2011 and 2012. The baseline NCCR was determined as creatinine (mg/dL)/cystatin C (mg/L)×10/body mass (kg). CMM was defined as the simultaneous occurrence of two or more of the following conditions: heart disease, stroke, and type 2 diabetes mellitus. Logistic regression analysis and Cox regression analysis were employed to estimate the relationship between NCCR and CMM. The joint effect of body mass index and NCCR on the risk of CMM were further analyzed.

Results: During a median 4-year follow-up, 227 (3.9%) participants developed CMM. The risk of CMM was significantly decreased with per standard deviation increase of NCCR (odds ratio, 0.72; 95% confidence interval, 0.62 to 0.85) after adjustment for confounders (P<0.001). Further sex-specific analysis found significant negative associations between NCCR and CMM in female either without or with one CMM component at baseline, which was attenuated in males but remained statistically significant among those with one basal CMM component. Notably, non-obese individuals with high NCCR levels had the lowest CMM risk compared to obese counterparts with low NCCR levels in both genders.

Conclusion: High NCCR was independently associated with reduced risk of CMM in middle-aged and older adults in China, particularly females.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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