利用间充质干细胞和内皮细胞联合Apelin创新治疗老年性听力损失。

IF 5.3 2区医学 Q2 CELL BIOLOGY

Cell Biology and Toxicology Pub Date : 2025-01-17 DOI:10.1007/s10565-025-09988-4

Shengqun Xu, Dongliang Liu, Fang Zhang, Yuan Tian

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引用次数: 0

摘要

利用单细胞转录组测序（scRNA-seq）技术，本研究探讨了利用间充质干细胞（MSCs）作为年龄相关性听力损失（ARHL）治疗方法的可行性。该研究表明MSCs能够分化为内耳细胞亚群，特别是毛细胞，通过细胞外囊泡（EVs）传递Apelin，促进M2巨噬细胞极化。体外实验表明，减少炎症和保持毛细胞健康。在老年小鼠中，MSCs移植导致毛细胞再生，恢复听觉功能。这些发现强调了间充质干细胞的再生能力和ev介导的ARHL治疗方法。

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Innovative treatment of age-related hearing loss using MSCs and EVs with Apelin.

Utilizing single-cell transcriptome sequencing (scRNA-seq) technology, this study explores the viability of employing mesenchymal stem cells (MSCs) as a therapeutic approach for age-related hearing loss (ARHL). The research demonstrates MSCs' ability to differentiate into inner ear cell subpopulations, particularly hair cells, delivering Apelin via extracellular vesicles (EVs) to promote M2 macrophage polarization. In vitro experiments show reduced inflammation and preservation of hair cell health. In elderly mice, MSCs transplantation leads to hair cell regeneration, restoring auditory function. These findings highlight the regenerative capabilities of MSCs and EV-mediated therapeutic approaches for ARHL.

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来源期刊

Cell Biology and Toxicology 生物-毒理学

CiteScore

9.90

自引率

4.90%

发文量

101

审稿时长

>12 weeks

期刊介绍： Cell Biology and Toxicology (CBT) is an international journal focused on clinical and translational research with an emphasis on molecular and cell biology, genetic and epigenetic heterogeneity, drug discovery and development, and molecular pharmacology and toxicology. CBT has a disease-specific scope prioritizing publications on gene and protein-based regulation, intracellular signaling pathway dysfunction, cell type-specific function, and systems in biomedicine in drug discovery and development. CBT publishes original articles with outstanding, innovative and significant findings, important reviews on recent research advances and issues of high current interest, opinion articles of leading edge science, and rapid communication or reports, on molecular mechanisms and therapies in diseases.