嗜麦芽窄养单胞菌中clc型整合和共轭元件传播的证据，介导sul1和其他抗性决定因素的获得。

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-02-13 Epub Date: 2025-01-16 DOI:10.1128/aac.01554-24

Selene Rebecca Boncompagni, Eleonora Riccobono, Maria Grazia Cusi, Vincenzo Di Pilato, Gian Maria Rossolini

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引用次数: 0

摘要

一株嗜麦芽寡养单胞菌blaVIM-1金属β -内酰胺酶基因阳性，对甲氧苄啶-磺胺甲恶唑耐药，意外地从直肠监测拭子中分离出来。菌株的特征显示携带一个91 kb的整合和共轭元件（ICE），包含几个抗性决定因子[sul1， blaVIM-1, aac(6')-Ib, aac(6')-31, qacE∆1，cold和merEDAPTR]，与铜绿假单胞菌和其他假单胞菌中广泛存在的一组clc型ICE密切相关。结果表明，嗜麦芽葡萄球菌可能传播了类似的元素，介导了相关抗性的获得。

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Evidence of dissemination of a clc-type integrative and conjugative element to Stenotrophomonas maltophilia, mediating acquisition of sul1 and other resistance determinants.

A Stenotrophomonas maltophilia strain positive for the bla_VIM-1 metallo-beta-lactamase gene and resistant to trimethoprim-sulfamethoxazole was unexpectedly isolated from a surveillance rectal swab. The characterization of the strain revealed carriage of a 91 kb integrative and conjugative element (ICE) harboring several resistance determinants [sul1, bla_VIM-1, aac(6')-Ib, aac(6')-31, qacE∆1, cld, and merEDAPTR], closely related with a group of clc-type ICEs widespread among Pseudomonas aeruginosa and other pseudomonads. Results highlighted the possible spreading of similar elements to S. maltophilia, mediating the acquisition of relevant resistances.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.