Andrew W D'Souza, Sarah L Hissen, Kazumasa Manabe, Takuro Washio, Meghan C Annis, Belinda Sanchez, Charlotte W Usselman, Qi Fu, J Kevin Shoemaker
{"title":"口服避孕药对年轻女性静止交感神经传导的影响。","authors":"Andrew W D'Souza, Sarah L Hissen, Kazumasa Manabe, Takuro Washio, Meghan C Annis, Belinda Sanchez, Charlotte W Usselman, Qi Fu, J Kevin Shoemaker","doi":"10.1152/ajpheart.00623.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Although previous work has demonstrated that oral contraceptive pill (OCP) use does not affect resting muscle sympathetic nerve activity (MSNA), growing evidence indicates that it attenuates neurogenic vasoconstriction. Despite these advances, it remains unknown how OCP use affects the ability of MSNA to dynamically control vascular tone and arterial blood pressure (BP) on a beat-by-beat basis. Thus, we tested the hypothesis that, compared with naturally menstruating females (MC), those using OCPs will exhibit attenuated sympathetic vascular transduction at rest. Forty-three females [MC: <i>n</i> = 21, 26 (4) yrs; OCP: <i>n</i> = 22, 24 (4) yrs; data are presented as means (SD)] completed 10 min of supine rest with continuous measurements of beat-by-beat BP, femoral artery blood flow (26 females; MC: <i>n</i> = 13, OCP: <i>n</i> = 13), and MSNA. Spike-triggered averaging was used to determine sympathetic transduction into leg vascular conductance (LVC) and BP for 12 cardiac cycles following MSNA bursts. Overall sympathetic-BP transduction (<i>P</i> = 0.293), as well as sympathetic-BP transduction of MSNA burst quartiles (<i>P</i> = 0.741) and burst firing patterns (<i>P</i> = 0.452) were not different between the MC and OCP groups. Conversely, sympathetic vascular transduction per unit MSNA burst amplitude (<i>P</i> = 0.026) and burst firing pattern (<i>P</i> = 0.014) were attenuated among females using OCPs. In addition, females using OCPs demonstrated progressively smaller leg vasoconstrictor responses as a function of MSNA burst firing pattern compared with MC females (<i>P</i> = 0.021). Collectively, these data indicate that, in premenopausal females, OCP use attenuates the leg vasoconstrictor responses to bursts of MSNA, particularly during periods of increased sympathetic neural drive, without affecting the transduction of MSNA bursts into beat-by-beat changes in BP.<b>NEW & NOTEWORTHY</b> This study investigated the impact of OCP use on the transduction of MSNA bursts into regional vasoconstriction and blood pressure in premenopausal females. We demonstrated that females using OCPs exhibit attenuated sympathetic transduction into LVC; however, this does not translate to reductions in sympathetic blood pressure transduction. Collectively, these data indicate that OCP use may alter the local vasoconstrictor response to bursts of MSNA; however, compensatory mechanisms may contribute to maintain sympathetic blood pressure transduction.</p>","PeriodicalId":7692,"journal":{"name":"American journal of physiology. Heart and circulatory physiology","volume":"328 2","pages":"H271-H282"},"PeriodicalIF":4.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The impact of oral contraceptive pill use on sympathetic transduction at rest in young females.\",\"authors\":\"Andrew W D'Souza, Sarah L Hissen, Kazumasa Manabe, Takuro Washio, Meghan C Annis, Belinda Sanchez, Charlotte W Usselman, Qi Fu, J Kevin Shoemaker\",\"doi\":\"10.1152/ajpheart.00623.2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Although previous work has demonstrated that oral contraceptive pill (OCP) use does not affect resting muscle sympathetic nerve activity (MSNA), growing evidence indicates that it attenuates neurogenic vasoconstriction. Despite these advances, it remains unknown how OCP use affects the ability of MSNA to dynamically control vascular tone and arterial blood pressure (BP) on a beat-by-beat basis. Thus, we tested the hypothesis that, compared with naturally menstruating females (MC), those using OCPs will exhibit attenuated sympathetic vascular transduction at rest. Forty-three females [MC: <i>n</i> = 21, 26 (4) yrs; OCP: <i>n</i> = 22, 24 (4) yrs; data are presented as means (SD)] completed 10 min of supine rest with continuous measurements of beat-by-beat BP, femoral artery blood flow (26 females; MC: <i>n</i> = 13, OCP: <i>n</i> = 13), and MSNA. Spike-triggered averaging was used to determine sympathetic transduction into leg vascular conductance (LVC) and BP for 12 cardiac cycles following MSNA bursts. Overall sympathetic-BP transduction (<i>P</i> = 0.293), as well as sympathetic-BP transduction of MSNA burst quartiles (<i>P</i> = 0.741) and burst firing patterns (<i>P</i> = 0.452) were not different between the MC and OCP groups. Conversely, sympathetic vascular transduction per unit MSNA burst amplitude (<i>P</i> = 0.026) and burst firing pattern (<i>P</i> = 0.014) were attenuated among females using OCPs. In addition, females using OCPs demonstrated progressively smaller leg vasoconstrictor responses as a function of MSNA burst firing pattern compared with MC females (<i>P</i> = 0.021). Collectively, these data indicate that, in premenopausal females, OCP use attenuates the leg vasoconstrictor responses to bursts of MSNA, particularly during periods of increased sympathetic neural drive, without affecting the transduction of MSNA bursts into beat-by-beat changes in BP.<b>NEW & NOTEWORTHY</b> This study investigated the impact of OCP use on the transduction of MSNA bursts into regional vasoconstriction and blood pressure in premenopausal females. We demonstrated that females using OCPs exhibit attenuated sympathetic transduction into LVC; however, this does not translate to reductions in sympathetic blood pressure transduction. Collectively, these data indicate that OCP use may alter the local vasoconstrictor response to bursts of MSNA; however, compensatory mechanisms may contribute to maintain sympathetic blood pressure transduction.</p>\",\"PeriodicalId\":7692,\"journal\":{\"name\":\"American journal of physiology. Heart and circulatory physiology\",\"volume\":\"328 2\",\"pages\":\"H271-H282\"},\"PeriodicalIF\":4.1000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of physiology. Heart and circulatory physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/ajpheart.00623.2024\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of physiology. Heart and circulatory physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/ajpheart.00623.2024","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/7 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
虽然先前的研究表明口服避孕药(OCP)的使用不会影响静息肌交感神经活动(MSNA),但越来越多的证据表明它可以减轻神经源性血管收缩。尽管取得了这些进展,但目前仍不清楚OCP的使用如何影响MSNA动态控制血管张力和动脉血压(BP)的能力。因此,我们验证了这样的假设,即与自然月经的女性(MC)相比,使用ocp的女性在休息时交感血管传导减弱。女性43例[MC: n = 21,26(4)岁;OCP: n = 22,24(4)年;数据以均数(SD)表示]完成10分钟仰卧休息并连续测量逐拍血压、股动脉血流(26名女性;MC: n = 13, OCP: n = 13), MSNA。采用峰值触发平均法测定MSNA爆发后12个心动周期内交感神经传导到腿部血管传导(LVC)和血压的变化。整体交感- bp转导(P = 0.293),以及MSNA突发四分位数的交感- bp转导(P = 0.741)和突发放电模式(P = 0.452)在MC组和OCP组之间没有差异。相反,在使用ocp的女性中,单位MSNA爆发振幅的交感血管转导(P = 0.026)和爆发放电模式(P = 0.014)减弱。此外,使用ocp的女性与使用MC的女性相比,其腿部血管收缩反应随着MSNA爆发放电模式的变化而逐渐减弱(P = 0.021)。总的来说,这些数据表明,在绝经前女性中,OCP的使用减弱了腿部血管收缩剂对MSNA爆发的反应,特别是在交感神经驱动增强的时期,而不影响MSNA爆发转化为血压的逐次变化。新的和值得注意的是,本研究调查了使用OCP对绝经前女性MSNA爆发转化为局部血管收缩和血压的影响。我们发现使用ocp的雌性表现出减弱的交感神经传导到LVC;然而,这并不意味着交感血压传导的降低。总的来说,这些数据表明使用OCP可能会改变局部血管收缩剂对MSNA爆发的反应;然而,代偿机制可能有助于维持交感血压转导。
The impact of oral contraceptive pill use on sympathetic transduction at rest in young females.
Although previous work has demonstrated that oral contraceptive pill (OCP) use does not affect resting muscle sympathetic nerve activity (MSNA), growing evidence indicates that it attenuates neurogenic vasoconstriction. Despite these advances, it remains unknown how OCP use affects the ability of MSNA to dynamically control vascular tone and arterial blood pressure (BP) on a beat-by-beat basis. Thus, we tested the hypothesis that, compared with naturally menstruating females (MC), those using OCPs will exhibit attenuated sympathetic vascular transduction at rest. Forty-three females [MC: n = 21, 26 (4) yrs; OCP: n = 22, 24 (4) yrs; data are presented as means (SD)] completed 10 min of supine rest with continuous measurements of beat-by-beat BP, femoral artery blood flow (26 females; MC: n = 13, OCP: n = 13), and MSNA. Spike-triggered averaging was used to determine sympathetic transduction into leg vascular conductance (LVC) and BP for 12 cardiac cycles following MSNA bursts. Overall sympathetic-BP transduction (P = 0.293), as well as sympathetic-BP transduction of MSNA burst quartiles (P = 0.741) and burst firing patterns (P = 0.452) were not different between the MC and OCP groups. Conversely, sympathetic vascular transduction per unit MSNA burst amplitude (P = 0.026) and burst firing pattern (P = 0.014) were attenuated among females using OCPs. In addition, females using OCPs demonstrated progressively smaller leg vasoconstrictor responses as a function of MSNA burst firing pattern compared with MC females (P = 0.021). Collectively, these data indicate that, in premenopausal females, OCP use attenuates the leg vasoconstrictor responses to bursts of MSNA, particularly during periods of increased sympathetic neural drive, without affecting the transduction of MSNA bursts into beat-by-beat changes in BP.NEW & NOTEWORTHY This study investigated the impact of OCP use on the transduction of MSNA bursts into regional vasoconstriction and blood pressure in premenopausal females. We demonstrated that females using OCPs exhibit attenuated sympathetic transduction into LVC; however, this does not translate to reductions in sympathetic blood pressure transduction. Collectively, these data indicate that OCP use may alter the local vasoconstrictor response to bursts of MSNA; however, compensatory mechanisms may contribute to maintain sympathetic blood pressure transduction.
期刊介绍:
The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.