Current strategies in design and synthesis of antifungals hybrid and chimeric diazine derivatives.

In the last decades fungal infections became a major threat to human health having an unacceptably occurrence, a high rate of mortality and the number of patients at risk for these infections continue to increase every year. An effective, modern and very useful strategy in antifungal therapy is represented by the use of chimeric and hybrid drugs, most of them being with azaheterocycle skeleton. In this review, we present an overview from the last five years of the most representative achievements in the field of chimeric and hybrid diazine derivatives with antifungal properties. Within this work we emphasize the most relevant data concerning the synthesis, design, Structure Activity Relationships (SAR) correlations and antifungal activity of the main classes of diazine: 1,2-diazine (pyridazine), 1,3-diazine (pyrimidine), 1,4-diazine (pyrazine) and their fused derivatives.