CuTAllPyP4和CoTAllPyP4卟啉与DNA的吸附等温线结合参数

IF 0.5 4区 物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY
G. V. Ananyan, N. H. Karapetyan, Y. B. Dalyan, R. S. Ghazaryan, S. G. Haroutiunian
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引用次数: 0

摘要

基于光谱吸附等温线,比较了阳离子卟啉CuTAllPyP4和CoTAllPyP4与DNA的结合参数随溶液离子强度的变化。结果表明,无论离子强度如何,卟啉CoTAllPyP4与DNA的结合常数比CuTAllPyP4的结合常数低一个数量级。随着离子强度的增加,硬烯丙基侧自由基的存在增加了卟啉在DNA大分子上聚集并形成三明治状系综的倾向(h聚集体),这导致卟啉CuTAllPyP4和CoTAllPyP4的电子吸收光谱发生次色移,而与中心金属类型和空间结构无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms

Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms

A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (H-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure.

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来源期刊
CiteScore
1.00
自引率
66.70%
发文量
43
审稿时长
6-12 weeks
期刊介绍: Journal of Contemporary Physics (Armenian Academy of Sciences) is a journal that covers all fields of modern physics. It publishes significant contributions in such areas of theoretical and applied science as interaction of elementary particles at superhigh energies, elementary particle physics, charged particle interactions with matter, physics of semiconductors and semiconductor devices, physics of condensed matter, radiophysics and radioelectronics, optics and quantum electronics, quantum size effects, nanophysics, sensorics, and superconductivity.
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