G. V. Ananyan, N. H. Karapetyan, Y. B. Dalyan, R. S. Ghazaryan, S. G. Haroutiunian
{"title":"CuTAllPyP4和CoTAllPyP4卟啉与DNA的吸附等温线结合参数","authors":"G. V. Ananyan, N. H. Karapetyan, Y. B. Dalyan, R. S. Ghazaryan, S. G. Haroutiunian","doi":"10.1134/S106833722470035X","DOIUrl":null,"url":null,"abstract":"<p>A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (<i>H</i>-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure.</p>","PeriodicalId":623,"journal":{"name":"Journal of Contemporary Physics (Armenian Academy of Sciences)","volume":"59 3","pages":"347 - 352"},"PeriodicalIF":0.5000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms\",\"authors\":\"G. V. Ananyan, N. H. Karapetyan, Y. B. Dalyan, R. S. Ghazaryan, S. G. Haroutiunian\",\"doi\":\"10.1134/S106833722470035X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (<i>H</i>-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure.</p>\",\"PeriodicalId\":623,\"journal\":{\"name\":\"Journal of Contemporary Physics (Armenian Academy of Sciences)\",\"volume\":\"59 3\",\"pages\":\"347 - 352\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Contemporary Physics (Armenian Academy of Sciences)\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S106833722470035X\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Contemporary Physics (Armenian Academy of Sciences)","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1134/S106833722470035X","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Binding Parameters of CuTAllPyP4 and CoTAllPyP4 Porphyrins to DNA Using Adsorption Isotherms
A comparative study of the binding parameters of cationic porphyrins CuTAllPyP4 and CoTAllPyP4 with DNA was conducted based on spectroscopic adsorption isotherms depending on the ionic strength of the solution. The obtained results show that the binding constant of the porphyrin CoTAllPyP4 with DNA is an order of magnitude lower than the binding constant of CuTAllPyP4 regardless of the ionic strength. The presence of hard allylic side radicals with increasing ionic strength increases the tendency of porphyrins to aggregate and form sandwich-like ensembles on the DNA macromolecule (H-aggregates), which leads to a hypsochromic shift in the electronic absorption spectra of the porphyrins CuTAllPyP4 and CoTAllPyP4 regardless of the type of central metal and spatial structure.
期刊介绍：
Journal of Contemporary Physics (Armenian Academy of Sciences) is a journal that covers all fields of modern physics. It publishes significant contributions in such areas of theoretical and applied science as interaction of elementary particles at superhigh energies, elementary particle physics, charged particle interactions with matter, physics of semiconductors and semiconductor devices, physics of condensed matter, radiophysics and radioelectronics, optics and quantum electronics, quantum size effects, nanophysics, sensorics, and superconductivity.
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