第三代青光眼超声乳化小梁微搭桥植入术。
IF 2.6
3区 医学
Q2 OPHTHALMOLOGY
引用次数: 0
摘要
简介：这项回顾性、连续性、真实世界病例系列研究评估了第三代小梁微旁路支架植入术（iStent infinite）与超声乳化术在轻度至中度原发性开角型青光眼（POAG）患者中的疗效和安全性：方法：患者在接受超声乳化术的同时，由一名美国青光眼外科医生为其植入 iStent infinite（包含三个支架）。12个月后的结果包括平均眼压（IOP）和用药情况；眼压≤18 mmHg、≤15 mmHg或≤12 mmHg的眼睛比例；使用0、1、2或≥3种局部青光眼药物的眼睛比例；不良事件；以及继发性青光眼手术。结果显示了每个时间点所有可用眼的观察组群数据和术后 12 个月的一致组群数据：2023年2月至2024年6月期间，共有121只患有轻度（66.1%）或中度（33.9%）POAG的眼睛接受了iStent infinite植入术。在有 12 个月随访数据的眼球中（n = 32），平均眼压从术前的 18.1 ± 3.3 mmHg 降至 12 个月时的 13.8 ± 3.4 mmHg（降低 23.8%，p 结论：iStent 无限极植入术与白内障手术相结合，在临床和统计学上显著降低了眼压，术后 12 个月的用药量减少，安全性良好。该队列是该设备结合白内障手术实际应用的首批、也是最大的已发表数据集之一。本文章由计算机程序翻译，如有差异，请以英文原文为准。
Third-Generation Trabecular Micro-Bypass Implantation with Phacoemulsification for Glaucoma.
Introduction: This retrospective, consecutive, real-world case series assessed the efficacy and safety of third-generation trabecular micro-bypass stent implantation (iStent infinite) with phacoemulsification in patients with mild-to-moderate primary open-angle glaucoma (POAG).
Methods: Patients underwent phacoemulsification combined with implantation of iStent infinite (containing three stents) by a single U.S. glaucoma surgeon. Outcomes through 12 months included mean intraocular pressure (IOP) and medications; proportions of eyes with IOP ≤ 18 mmHg, ≤ 15 mmHg, or ≤ 12 mmHg; proportions of eyes on 0, 1, 2, or ≥ 3 topical glaucoma medications; adverse events; and secondary glaucoma procedures. Data are presented for the observed cohort of all available eyes at each time point and the consistent cohort of eyes with data at 12 months postoperative.
Results: A total of 121 eyes with mild (66.1%) or moderate (33.9%) POAG underwent iStent infinite implantation between February 2023 and June 2024. In eyes with 12-month follow-up data (n = 32), mean IOP reduced from 18.1 ± 3.3 mmHg preoperatively to 13.8 ± 3.4 mmHg at 12 months (23.8% reduction, p < 0.001), while mean number of medications reduced from 1.38 ± 0.91 to 1.06 ± 1.13 medications (23.2% reduction, p = 0.023). The proportions of eyes achieving IOP ≤ 18/15/12 mmHg increased from 53.1%/21.9%/3.1% preoperatively to 87.5%/75.0%/43.8% at 12 months, respectively (all p < 0.01). Adverse events were largely mild and transient; three eyes (< 3%) had secondary laser or micro-invasive glaucoma interventions due to IOP and/or medications above goal.
Conclusions: iStent infinite implantation with cataract surgery resulted in clinically and statistically significant IOP and medication reductions through 12 months postoperative, with favorable safety. This cohort constitutes one of the first and largest published datasets for this device in combination with cataract surgery in real-world usage.
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来源期刊
Ophthalmology and Therapy
OPHTHALMOLOGY-
CiteScore
4.20
自引率
3.00%
发文量
157
审稿时长
6 weeks
期刊介绍：
Aims and Scope
Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals.
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The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies.
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All articles published by Ophthalmology and Therapy are open access.
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