Factors Influencing Recruitment, Retention, and Adherence Rates in Exercise Interventions in ESKD: A Scoping Review

Rational & Objective

Majority of people with end-stage kidney disease (ESKD) are sedentary, which increases risk for decreased quality and quantity of life. Development of exercise programs with characteristics that address individual preferences may increase interest in participating and completing exercise programs. We evaluated which exercise intervention characteristics affect exercise program recruitment, adherence, and completion in people with ESKD receiving dialysis.

Study Design

Scoping review of randomized controlled trials (RCTs) with searching of Medline, Embase, Cochrane, and CINAHL databases through May 12, 2023.

Setting & Study Populations

Adults with ESKD receiving dialysis.

Selection Criteria

RCTs with exercise interventions of ≥12 weeks that included more than 10 people with ESKD receiving dialysis in each study arm.

Data Extraction

One individual extracted data and the second author checked for accuracy.

Analytical Approach

Data were synthesized qualitatively. Associations between intervention characteristics and recruitment, retention and adherence rates were assessed through one-way analysis of variance tests. Risk of bias was assessed using the Cochrane Risk of Bias 1.0 tool.

Results

Of 7,396 studies identified, 55 studies with 3,269 trial participants were included. The majority of participants were male (63.2%) and treated with hemodialysis (89.1%). Mean age was 56 ± 11.5 years. Average recruitment, retention and adherence rates were 77.4%, 81.2%, and 76.0%, respectively. Only 27% of studies reported adherence rates. No significant associations were found between intervention characteristics (ie, exercise type, duration, frequency, setting, and supervision) and recruitment, adherence, and retention rates.

Limitations

Data were limited by small sample size, suboptimal risk of bias, selective recruiting methods, and variability in definitions of adherence rates.

Conclusion

Average recruitment, retention, and adherence rates in exercise interventions for patients receiving dialysis were high although less than 1 in 4 studies reported adherence rates. These results call for standardized reporting of recruitment, retention, and adherence rates in exercise interventions.

Plain-Language Summary

Regular exercise for people with end-stage kidney disease (ESKD) can improve their quality of life. We sought to determine if there were certain characteristics of an exercise program such as exercise type, frequency, program length, and setting that were associated with enhanced recruitment, retention, and adherence to the program. From the 55 identified studies, average recruitment, retention, and adherence rates in exercise interventions were high irrespective of the program characteristics. However, it is unclear if our results are robust as there was a lack of formalized definitions for recruitment, retention, and adherence rates. Moreover, very few studies reported adherence rates. Therefore, we suggest that standardized definitions and reporting of these factors be required in exercise studies.