洛杉矶一家大型学术机构研究西班牙裔非小细胞肺癌患者间变性淋巴瘤激酶改变的真实世界发生率。

IF 2 Q3 ONCOLOGY

Cancer research communications Pub Date : 2025-02-01 DOI:10.1158/2767-9764.CRC-24-0504

Darin Poei, Sana Ali, Jacob S Thomas, Jorge J Nieva, Robert C Hsu

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引用次数: 0

摘要

种族和民族影响非小细胞肺癌（NSCLC）患者分子改变的分布。虽然间变性淋巴瘤激酶（ALK）改变已知发生在4-5%的人群中，但针对西班牙裔人群的数据仍然有限。本研究描述了在美国加利福尼亚州洛杉矶一家大型学术机构接受治疗的西班牙裔非小细胞肺癌患者ALK改变的真实发生率，以进一步阐明形成突变谱差异的潜在因素。从2015年1月到2023年6月，在洛杉矶综合医疗中心（n=172）和南加州大学诺里斯综合癌症中心（n=435）接受综合基因组分析（CGP）治疗的607例非小细胞肺癌（NSCLC）患者进行了评估。采用Fisher精确检验和多元逻辑回归进行统计分析。西班牙裔患者ALK改变发生率（12.76%,n=18/141）高于非西班牙裔患者（5.36%,n=23/466）（p=0.0046）。多因素logistic回归显示，西班牙裔HR 2.393 （95% CI 1.115 ~ 5.092）和诊断年龄HR 0.9325 （95% CI 0.9081 ~ 0.9558）是影响ALK改变发生率的重要因素。55.81% （n=24）的ALK改变最初是通过综合基因组分析（CGP）发现的。这项研究强调了西班牙裔非小细胞肺癌患者中ALK改变的发生率明显更高，强调了种族和民族对分子改变的影响。未来的研究需要在更大、更多样化的队列中评估这一趋势，并调查环境因素和肿瘤微环境在影响ALK改变患病率中的作用。

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Real-World Incidence of Anaplastic Lymphoma Kinase Alterations in Hispanics with Non-Small Cell Lung Cancer at a Large Academic Institution in Los Angeles.

Significance: This study identified a higher incidence of ALK alterations in Hispanic patients with NSCLC (12.76%) compared with that in non-Hispanic patients (5.36%) treated at a large academic center in Los Angeles, highlighting the impact of race on molecular alteration profiles and emphasizing the need to increase access to molecular analyses for this population. The variability in mutational alterations may be influenced by biological and environmental factors.

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Cancer research communications

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