Visible-light-driven Anion Relay Chemistry (ARC): Construction of Fully Substituted Pyrazoles

Anion relay chemistry (ARC) is a multi-component union strategy that has emerged as a powerful approach for synthesizing complex structures. However, previous studies have primarily concentrated on thermally controlled reaction modes. In this study, we report the development of an unprecedented visible-light-driven anion relay chemistry (ARC) strategy. Utilizing an energy-transfer process, we successfully transformed tosylhydrazones into anionic donors, facilitating the synthesis of fully substituted pyrazole derivatives under mild conditions. Furthermore, a combination of experimental mechanistic investigations and computational studies (DFT) not only corroborated the proposed mechanism of the reaction but also inspired additional avenues for future research.