内皮或线粒体水平治疗:败血症的新领域?

Rashmi Datta, Shalendra Singh
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引用次数: 0

摘要

宿主和微生物在平衡导致败血症的促炎和抗炎途径方面发挥着复杂的作用。现在越来越多的人认为它是线粒体系统的一种疾病,或者是微循环异常导致低灌注/缺氧的结果(“微循环和线粒体窘迫综合征”)。预计内皮或线粒体水平治疗的改善将降低败血症相关的发病率和死亡率。本文旨在阐明脓毒症患者的线粒体和微循环异常以及脓毒症治疗的未来研究议程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The endothelium or mitochondrial level therapy: new frontiers in sepsis?

The host and microbes play complex roles in balancing the pro- and anti-inflammatory pathways that cause sepsis. It is now increasingly recognized as a disorder of the mitochondrial system intrinsically or as a consequence of microcirculatory abnormalities leading to hypoperfusion/hypoxia ("microcirculatory and mitochondrial distress syndrome"). It is expected that improvements in endothelium or mitochondrial level therapy will lower sepsis-related morbidity and mortality. This article aimed to clarify the mitochondrial and microcirculation abnormalities in patients with sepsis and the futuristic research agenda for the management of sepsis.

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