放射发光成像在微束放射治疗中的实时剂量测量。

IF 3.3 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Physica Medica-European Journal of Medical Physics Pub Date : 2025-02-01 DOI:10.1016/j.ejmp.2025.104894

Francesca Marson , Stefano Pizzardi , Lisa Alborghetti , Federica Vurro , Maria Assunta Lacavalla , Claudio Fiorino , Antonello E. Spinelli

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引用次数: 0

摘要

目的：微束放射治疗（MBRT）使用小的平行辐射束来产生高度调制的剂量模式。本研究的目的是开发一种光学放射发光成像（RLI）方法，用于MBRT的实时剂量测量。方法：使用配备定制准直器的图像引导小动物辐照器进行MBRT传递。将厚度分别为0.5、1、2、3和10 mm的5块塑料闪烁体板放置在小鼠幻体上，用于定位和测量给药剂量。用一层薄薄的放射发光膜（Gd2O2S:Tb）获得了微束剂量谱，并与GafChromic （GC）薄膜测量结果进行了比较。RLI信号被放置在与光束轴90度的CMOS相机检测到。利用TOPAS进行了蒙特卡罗（MC）模拟，与实验结果进行了比较。结果：RLI法测得的峰谷剂量比（PVDR）为16.7，与气相膜测定值一致。相对于GC测量，峰谷尺寸之间的差异小于3%。使用闪烁体板进行RLI，可以定位和测量实时MBRT在小鼠幻体上的传递。结论：我们提出了一种基于RLI的MBRT剂量定位和实时测量的新方法。所得结果与气相色谱膜测量值吻合较好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Real-time dose measurement in minibeam radiotherapy using radioluminescence imaging

Purpose:

Minibeam radiotherapy (MBRT) uses small parallel beams of radiation to create a highly modulated dose pattern. The aim of this study is to develop an optical radioluminescence imaging (RLI) approach to perform real-time dose measurement for MBRT.

Methods:

MBRT was delivered using an image-guided small animal irradiator equipped with a custom collimator. Five slabs of plastic scintillators with a thicknesses of 0.5, 1, 2, 3 and 10 mm were placed on top of a mouse phantom, to localize and measure the delivered dose. A thin radioluminescence film (

G d_{2} O_{2} S : T b

) was used to obtain the mini beam dose profile that was compared against GafChromic (GC) films measurements. The RLI signal was detected with a CMOS camera placed at 90 deg with respect to the beam axis. Monte Carlo (MC) simulations were also performed using TOPAS for comparison with the experimental results.

Results:

The measured peak to valley dose ratio (PVDR) obtained with RLI was 16.7 in line with GC films measurements. The differences between peak and valley dimension were less that 3% with respect to GC measurements. Using RLI performed with the scintillator slabs, it was possible to localize and measure in real-time MBRT delivery on the mouse phantom.

Conclusions:

We proposed a novel method for MBRT dose localization and measurement in real-time based on RLI. The results we obtained are in good agreement with GC film measurements.

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来源期刊

Physica Medica-European Journal of Medical Physics 生物-生物物理

CiteScore

6.80

自引率

14.70%

发文量

493

审稿时长

78 days

期刊介绍： Physica Medica, European Journal of Medical Physics, publishing with Elsevier from 2007, provides an international forum for research and reviews on the following main topics: Medical Imaging Radiation Therapy Radiation Protection Measuring Systems and Signal Processing Education and training in Medical Physics Professional issues in Medical Physics.