C Mauri, C Cerulli, E Grazioli, C Minganti, E Tranchita, A Scotto di Palumbo, A Parisi
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Direct comparison of different training treatment options on functional capacity and inflammatory biomarkers for OA is not currently feasible in practice, due to the heterogeneity of the test and the small number of studies. 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引用次数: 0
摘要
背景：骨关节炎（OA）是一种复杂的疾病，会引起疼痛、僵硬和肿胀，限制功能和活动，从而干扰日常生活，影响个人、社会和心理方面的生活：目的：证明运动对减轻疼痛的作用，以及在减轻 OA 患者疼痛、提高功能和炎症生物标志物方面，一种训练方式比另一种训练方式更有效：对从 Web of Science、PubMed 和 Scopus 数据库中检索到的研究进行了系统性审查。方法：对从 Web Science、PubM 和 Scopus 数据库中检索到的研究进行了系统综述，纳入了对 OA 患者进行体育锻炼干预的研究。系统综述考虑的三个主要结果是疼痛、功能能力和炎症生物标志物。针对每种结果分析了不同类型干预措施（有氧运动、阻力运动、综合运动、神经肌肉运动及其他）的效果。系统综述和荟萃分析均按照 PRISMA 声明进行。结果：21 项研究被纳入系统综述，11 项研究被纳入荟萃分析。荟萃分析针对的是训练干预亚组中的疼痛，结果显示神经肌肉训练的效应大小为-2,26（95 % CI -4,37 至-0,14）。功能能力和炎症生物标志物仅通过系统综述进行了分析，因为无法通过荟萃分析估计不同训练方案的疗效：结论：神经肌肉训练方案似乎对减轻 OA 疼痛最有效。由于测试的异质性和研究数量较少，直接比较不同训练治疗方案对 OA 功能能力和炎症生物标志物的影响目前在实践中并不可行。有必要进行高质量的体育锻炼干预研究，以更准确地评估其对 OA 患者疼痛、功能能力和炎症状态的有效性：CRD42023481061。
Role of exercise on pain, functional capacity, and inflammatory biomarkers in osteoarthritis: A systematic review and meta-analysis.
Background: Osteoarthritis (OA) is a complex disease that causes pain, stiffness and swelling, limiting function and mobility, thus interfering with daily life and affecting personal, social, and psychological aspects of life.
Objective: To evidence the role of exercise on pain reduction and the effectiveness of one type of training over another in terms of pain, functional capacity, and inflammatory biomarkers in OA.
Methods: Studies retrieved from Web of Science, PubMed and Scopus databases were systematically reviewed. RCTs involving physical exercise interventions in participants with OA were included. The 3 main outcomes considered in the systematic review were pain, functional capacity and inflammatory biomarkers. The effects of different types of interventions (aerobic, resistance, combined, neuromuscular and others) were analysed for each outcome. Systematic review and meta-analysis were conducted following the PRISMA Statement.
Results: 21 studies were included in the systematic review and 11 in the meta-analysis. The meta-analysis was conducted on pain in training intervention subgroups, showing a larger effect size for neuromuscular training -2,26 (95 % CI -4,37 to -0,14). Functional capacity and inflammatory biomarkers were analysed only with a systematic review because it was not possible to estimate the efficacy of the different training protocols with a meta-analysis.
Conclusion: Neuromuscular training protocols seem to be the most effective in reducing pain in OA. Direct comparison of different training treatment options on functional capacity and inflammatory biomarkers for OA is not currently feasible in practice, due to the heterogeneity of the test and the small number of studies. High-quality physical exercise intervention studies are warranted to estimate their effectiveness more accurately on pain, functional capacity, and inflammatory status in OA.
期刊介绍：
Annals of Physical and Rehabilitation Medicine covers all areas of Rehabilitation and Physical Medicine; such as: methods of evaluation of motor, sensory, cognitive and visceral impairments; acute and chronic musculoskeletal disorders and pain; disabilities in adult and children ; processes of rehabilitation in orthopaedic, rhumatological, neurological, cardiovascular, pulmonary and urological diseases.
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