Alexander G. Dragnich, Kaitlyn C. Chapin, Ke Xu, Jinyuan Liu, Loren Lipworth, Ciara M. Shaver, Anil J. Trindade
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引用次数: 0
摘要
心理韧性对肺移植结果的重要性尚不清楚。我们进行了一项初步研究，以评估移植前砂砾和恢复力是否与移植后短期结果相关。我们招募了31名肺移植候选人，其中7名（26%）具有更强的精神韧性，在我们的队列中被定义为毅力和恢复力的上限。心理韧性较高和较低患者的基线特征无差异。更强的精神韧性与更短的住院时间（LOS）相关[12天（四分位数范围，IQR 10-12）比17天（IQR 14-24）， p = 0.02]和创伤后应激严重程度降低[中位数0 （IQR 0-2）比6.5 (IQR 4-9), p < 0.01]。在调整年龄和杜克活动状态指数的多变量分析中，更强的精神韧性与更短的医院LOS [β = -11.96 (95% CI 0.05-23.86), p < 0.05]和更少的PTSD [β = -10.7 (95% CI -21.6-0.04), p = 0.053]相关。具有较强心理韧性的肺移植候选者可能有较好的短期预后。
Association of Grit and Resilience With Short-Term Post-Transplant Outcomes in Lung Allograft Recipients
The importance of mental toughness on lung transplant outcomes is unknown. We performed a pilot study to assess whether pretransplant grit and resilience are associated with short-term posttransplant outcomes. We enrolled 31 lung transplant candidates, of whom 7 (26%) had greater mental toughness, defined as the upper tertile for both grit and resilience within our cohort. There were no differences in baseline characteristics between patients with higher and lower mental toughness. Greater mental toughness was associated with a shorter hospital length of stay (LOS) [12 days (interquartile range, IQR 10–12) vs. 17 days (IQR 14–24), p = 0.02] and reduced posttraumatic stress severity [median 0 (IQR 0–2) vs. 6.5 (IQR 4–9), p < 0.01]. On multivariable analyses adjusting for age and Duke Activity Status Index, greater mental toughness was associated with a shorter hospital LOS [beta = −11.96 (95% CI 0.05–23.86), p < 0.05] and reduced PTSD [beta = −10.7 (95% CI −21.6–0.04), p = 0.053]. Lung transplant candidates with greater mental toughness may have improved short-term outcomes.
期刊介绍：
Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored.
Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include:
Immunology and immunosuppression;
Patient preparation;
Social, ethical, and psychological issues;
Complications, short- and long-term results;
Artificial organs;
Donation and preservation of organ and tissue;
Translational studies;
Advances in tissue typing;
Updates on transplant pathology;.
Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries.
Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.
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