连叶草苷I的碳-14放射性标记

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-13 DOI:10.1021/acs.orglett.4c04537

Goran Petrović, Jonathan Bristow, Steven F. Sukits, Nitesh Panchal, Indra Prakash

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引用次数: 0

摘要

公开了利用未标记材料开发的合成路线合成放射性标记的[25-14C]- simenoside I。该合成的特点是通过氧化裂解-重建策略和由保护基团操作指导的区域选择性糖基化对mogrol的C25进行早期标记。该途径为体内ADME和PK研究提供了足够量的[25-14C]- simenoside I。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Radiolabeling of Siamenoside I with Carbon-14

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Radiolabeling of Siamenoside I with Carbon-14

The synthesis of radiolabeled [25-¹⁴C]-siamenoside I following a synthetic route developed using unlabeled materials is disclosed. The synthesis features an early stage labeling of the mogrol’s C25 via an oxidative cleavage–reconstruction strategy and regioselective glycosylations directed by protecting group manipulations. This route provided access to adequate amounts of [25-¹⁴C]-siamenoside I for in vivo ADME and PK studies.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.