外泌体在癌症治疗中的新作用：进展和挑战

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cancer Pub Date : 2025-01-13 DOI:10.1186/s12943-024-02215-4

Jiale Li, Jiachong Wang, Zigui Chen

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引用次数: 0

摘要

这篇综述重点介绍了基于外泌体的癌症治疗药物递送的最新进展，涵盖了外泌体的生物生成、货物选择机制及其在多种癌症类型中的应用。外泌体是一种小的细胞外囊泡，具有生物相容性高、免疫原性低的特点，因此是理想的给药载体，能够有效地靶向癌细胞，最大限度地减少脱靶损伤和副作用。本综述旨在探讨外泌体在癌症治疗中的潜力，重点关注其在化疗、基因治疗和免疫调节中的应用。此外，还分析了与外泌体生产和标准化相关的挑战，强调了解决这些问题对其临床应用的重要性。总之，基于外泌体的给药系统为未来的癌症疗法提供了广阔的前景。进一步的研究应以提高生产效率和促进临床转化为目标，为创新的癌症治疗策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging role of exosomes in cancer therapy: progress and challenges

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple cancer types. As small extracellular vesicles, exosomes exhibit high biocompatibility and low immunogenicity, making them ideal drug delivery vehicles capable of efficiently targeting cancer cells, minimizing off-target damage and side effects. This review aims to explore the potential of exosomes in cancer therapy, with a focus on applications in chemotherapy, gene therapy, and immunomodulation. Additionally, challenges related to exosome production and standardization are analyzed, highlighting the importance of addressing these issues for their clinical application. In conclusion, exosome-based drug delivery systems offer promising potential for future cancer therapies. Further research should aim to enhance production efficiency and facilitate clinical translation, paving the way for innovative cancer treatment strategies.

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.