EWSR1::BEND2气管透明样假性腺癌。

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-01-07 DOI:10.1007/s12105-024-01746-y

Juan J Sanchez-Ramirez, Matthew R Hoffman, John C Keech, Anthony N Snow, Andrew M Bellizzi, Anand Rajan

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引用次数: 0

摘要

我们描述了一个新的发生的腺癌涉及气管，具有明显的实体和腺成分，在一个34岁的病人。我们阐述了其形态学和免疫表型特征，并描述了通过下一代测序（NGS）检测到的EWSR1::BEND2基因融合的分子发现。我们将这些发现与迄今为止文献中报道的头颈部bend2融合相关肿瘤进行比较。

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EWSR1::BEND2 Adenocarcinoma with Hyaline Pseudorosettes of the Trachea.

We describe the novel occurrence of a adenocarcinoma involving the trachea, with distinct solid and glandular components, in a 34-year-old patient. We illustrate its morphological and immunophenotypic features and describe the molecular finding of an EWSR1::BEND2 gene fusion detected by next-generation sequencing (NGS). We discuss the findings in comparison to BEND2-fusion associated neoplasms reported in the head and neck region in the literature to date.

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.