【胰腺炎遗传发病机制及基因治疗研究进展】。

Q4 Medicine

中华医学遗传学杂志 Pub Date : 2025-01-10 DOI:10.3760/cma.j.cn511374-20240814-00442

Yizhou Zheng, Yuanchen Wang, Wenbin Zou

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引用次数: 0

摘要

胰腺炎是一种受环境和遗传因素共同影响的炎症性疾病。它在世界范围内具有很高的患病率和死亡率，没有根治方法。近年来，胰腺炎的遗传学研究取得了突破性进展。易感基因和通路不断被发现，遗传因素在高甘油三酯血症和慢性胰腺炎中的作用日益突出。基因疗法可能为胰腺炎提供根治，尽管它仍处于研究阶段。本文就胰腺炎的遗传发病机制及基因治疗的研究现状进行综述，以期为胰腺炎的彻底治愈提供参考。

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[Research advances on the genetic pathogenesis and gene therapy for pancreatitis].

Pancreatitis is an inflammatory disease influenced by both environmental and genetic factors. It has a high prevalence and mortality rate worldwide, with no radical cure. Breakthroughs have been recently made in genetic research of pancreatitis. Susceptibility genes and pathways have been continuously discovered, which highlighted the roles of genetic factors in hypertriglyceridemic and chronic pancreatitis. Gene therapy may offer radical cure for pancreatitis, though it has remained at the research phase. This article has reviewed the genetic pathogenesis of pancreatitis and current status of gene therapy research, with an aim to provide a reference for attaining definitive cure for the disease.

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来源期刊

中华医学遗传学杂志 Medicine-Medicine (all)

CiteScore

0.50

自引率

0.00%

发文量

9521

期刊介绍： Chinese Journal of Medical Genetics is a medical journal, founded in 1984, under the supervision of the China Association for Science and Technology, sponsored by the Chinese Medical Association (hosted by Sichuan University), and is now a monthly magazine, which attaches importance to academic orientation, adheres to the scientific, scholarly, advanced, and innovative, and has a certain degree of influence in the industry. Chinese Journal of Medical Genetics is a journal of Peking University, and is now included in Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of Chinese Science Citation Database (with extended version), Statistical Source Journals (China Science and Technology Dissertation Outstanding Journals), Zhi.com (in Chinese), Wipu (in Chinese), Wanfang (in Chinese), CA Chemical Abstracts (U.S.), JST (Japan Science and Technology Science and Technology), and JST (Japan Science and Technology Science and Technology Research Center). ), JST (Japan Science and Technology Agency), Pж (AJ) Abstracts Journal (Russia), Copernicus Index (Poland), Cambridge Scientific Abstracts, Abstracts and Citation Database, Abstracts Magazine, Medical Abstracts, and so on.