{"title":"2型糖尿病患者血清腺苷脱氨酶水平与糖尿病足溃疡风险的相关性","authors":"Jing Wang, Ting Jiang, Shanshan Hu, Ling Zhou, Yanling Zheng, Wei Wang","doi":"10.11817/j.issn.1672-7347.2024.240297","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Adenosine deaminase (ADA) is a critical enzyme in the catabolism of adenosine acid during purine metabolism and plays a significant role in the diagnosis and monitoring of various diseases. This study aims to investigate the relationship between serum ADA levels and risk of diabetic foot ulcers (DFU) in patients with type 2 diabetes mellitus (T2DM), providing a clinical basis for the prevention and treatment of DFU.</p><p><strong>Methods: </strong>A retrospective study was conducted on 2 719 T2DM patients diagnosed at the Southwest Hospital of Army Medical University from January 2019 to January 2020. Patients were divided into a non-DFU group (<i>n</i>=1 952) and a DFU group (<i>n</i>=767) based on the presence of DFU. Serum ADA levels were collected, and participants were divided into quartiles: Q1, Q2, Q3, and Q4. Spearman correlation analysis and multivariate logistic regression were used to assess the relationship between serum ADA levels and DFU risk in T2DM patients. Additionally, changes in serum ADA levels among DFU patients with different Wagner grades were compared.</p><p><strong>Results: </strong>The prevalence of DFU in T2DM patients was 28.21%, and the prevalence increased with higher serum ADA levels. Multivariate-adjusted logistic regression analysis showed that for every 1-unit increase in serum ADA, the risk of DFU increased by 3% (<i>OR</i>=1.03, 95% <i>CI</i> 1.01 to 1.05, <i>P</i>=0.003). Compared with the Q1 group, the risk of DFU increased in the Q2 (<i>OR</i>=1.77, 95% <i>CI</i> 1.30 to 2.43, <i>P</i><0.001), Q3 (<i>OR</i>=2.11, 95% <i>CI</i> 1.54 to 2.89, <i>P</i><0.001), and Q4 (<i>OR</i>=2.27, 95% <i>CI</i> 1.64 to 3.16, <i>P</i><0.001) groups. Additionally, serum ADA levels increased with higher Wagner grades from 0 to 5 (<i>P</i><0.001).</p><p><strong>Conclusions: </strong>Elevated serum ADA levels in T2DM patients are associated with an increased risk of DFU, suggesting that serum ADA may play an important role in the development of DFU in T2DM patients.</p>","PeriodicalId":39801,"journal":{"name":"中南大学学报(医学版)","volume":"49 7","pages":"1015-1022"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495977/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation between serum adenosine deaminase levels and risk of diabetic foot ulcers in patients with type 2 diabetes mellitus.\",\"authors\":\"Jing Wang, Ting Jiang, Shanshan Hu, Ling Zhou, Yanling Zheng, Wei Wang\",\"doi\":\"10.11817/j.issn.1672-7347.2024.240297\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Adenosine deaminase (ADA) is a critical enzyme in the catabolism of adenosine acid during purine metabolism and plays a significant role in the diagnosis and monitoring of various diseases. This study aims to investigate the relationship between serum ADA levels and risk of diabetic foot ulcers (DFU) in patients with type 2 diabetes mellitus (T2DM), providing a clinical basis for the prevention and treatment of DFU.</p><p><strong>Methods: </strong>A retrospective study was conducted on 2 719 T2DM patients diagnosed at the Southwest Hospital of Army Medical University from January 2019 to January 2020. Patients were divided into a non-DFU group (<i>n</i>=1 952) and a DFU group (<i>n</i>=767) based on the presence of DFU. Serum ADA levels were collected, and participants were divided into quartiles: Q1, Q2, Q3, and Q4. Spearman correlation analysis and multivariate logistic regression were used to assess the relationship between serum ADA levels and DFU risk in T2DM patients. Additionally, changes in serum ADA levels among DFU patients with different Wagner grades were compared.</p><p><strong>Results: </strong>The prevalence of DFU in T2DM patients was 28.21%, and the prevalence increased with higher serum ADA levels. Multivariate-adjusted logistic regression analysis showed that for every 1-unit increase in serum ADA, the risk of DFU increased by 3% (<i>OR</i>=1.03, 95% <i>CI</i> 1.01 to 1.05, <i>P</i>=0.003). Compared with the Q1 group, the risk of DFU increased in the Q2 (<i>OR</i>=1.77, 95% <i>CI</i> 1.30 to 2.43, <i>P</i><0.001), Q3 (<i>OR</i>=2.11, 95% <i>CI</i> 1.54 to 2.89, <i>P</i><0.001), and Q4 (<i>OR</i>=2.27, 95% <i>CI</i> 1.64 to 3.16, <i>P</i><0.001) groups. Additionally, serum ADA levels increased with higher Wagner grades from 0 to 5 (<i>P</i><0.001).</p><p><strong>Conclusions: </strong>Elevated serum ADA levels in T2DM patients are associated with an increased risk of DFU, suggesting that serum ADA may play an important role in the development of DFU in T2DM patients.</p>\",\"PeriodicalId\":39801,\"journal\":{\"name\":\"中南大学学报(医学版)\",\"volume\":\"49 7\",\"pages\":\"1015-1022\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11495977/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中南大学学报(医学版)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.11817/j.issn.1672-7347.2024.240297\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中南大学学报(医学版)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.11817/j.issn.1672-7347.2024.240297","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的：腺苷脱氨酶（Adenosine deaminase， ADA）是嘌呤代谢过程中腺苷酸分解代谢的关键酶，在多种疾病的诊断和监测中具有重要作用。本研究旨在探讨2型糖尿病（T2DM）患者血清ADA水平与糖尿病足溃疡（DFU）发生风险的关系，为预防和治疗DFU提供临床依据。方法：对2019年1月至2020年1月在陆军军医大学西南医院诊断的2 719例2型糖尿病患者进行回顾性研究。根据有无DFU分为非DFU组（n= 1952）和DFU组（n=767）。收集血清ADA水平，并将参与者分为四分位数：Q1、Q2、Q3和Q4。采用Spearman相关分析和多因素logistic回归评估T2DM患者血清ADA水平与DFU风险的关系。此外，比较不同Wagner分级DFU患者血清ADA水平的变化。结果：T2DM患者DFU患病率为28.21%，且患病率随血清ADA水平升高而升高。多因素校正logistic回归分析显示，血清ADA每升高1个单位，DFU的发生风险增加3% （OR=1.03, 95% CI 1.01 ~ 1.05， P=0.003）。与Q1组相比，Q2组DFU发生风险增加（OR=1.77, 95% CI 1.30 ~ 2.43， POR=2.11, 95% CI 1.54 ~ 2.89， POR=2.27, 95% CI 1.64 ~ 3.16）。结论：T2DM患者血清ADA水平升高与DFU发生风险增加相关，提示血清ADA可能在T2DM患者DFU发生中起重要作用。
Correlation between serum adenosine deaminase levels and risk of diabetic foot ulcers in patients with type 2 diabetes mellitus.
Objectives: Adenosine deaminase (ADA) is a critical enzyme in the catabolism of adenosine acid during purine metabolism and plays a significant role in the diagnosis and monitoring of various diseases. This study aims to investigate the relationship between serum ADA levels and risk of diabetic foot ulcers (DFU) in patients with type 2 diabetes mellitus (T2DM), providing a clinical basis for the prevention and treatment of DFU.
Methods: A retrospective study was conducted on 2 719 T2DM patients diagnosed at the Southwest Hospital of Army Medical University from January 2019 to January 2020. Patients were divided into a non-DFU group (n=1 952) and a DFU group (n=767) based on the presence of DFU. Serum ADA levels were collected, and participants were divided into quartiles: Q1, Q2, Q3, and Q4. Spearman correlation analysis and multivariate logistic regression were used to assess the relationship between serum ADA levels and DFU risk in T2DM patients. Additionally, changes in serum ADA levels among DFU patients with different Wagner grades were compared.
Results: The prevalence of DFU in T2DM patients was 28.21%, and the prevalence increased with higher serum ADA levels. Multivariate-adjusted logistic regression analysis showed that for every 1-unit increase in serum ADA, the risk of DFU increased by 3% (OR=1.03, 95% CI 1.01 to 1.05, P=0.003). Compared with the Q1 group, the risk of DFU increased in the Q2 (OR=1.77, 95% CI 1.30 to 2.43, P<0.001), Q3 (OR=2.11, 95% CI 1.54 to 2.89, P<0.001), and Q4 (OR=2.27, 95% CI 1.64 to 3.16, P<0.001) groups. Additionally, serum ADA levels increased with higher Wagner grades from 0 to 5 (P<0.001).
Conclusions: Elevated serum ADA levels in T2DM patients are associated with an increased risk of DFU, suggesting that serum ADA may play an important role in the development of DFU in T2DM patients.
期刊介绍：
Journal of Central South University (Medical Sciences), founded in 1958, is a comprehensive academic journal of medicine and health sponsored by the Ministry of Education and Central South University. The journal has been included in many important databases and authoritative abstract journals at home and abroad, such as the American Medline, Pubmed and its Index Medicus (IM), the Netherlands Medical Abstracts (EM), the American Chemical Abstracts (CA), the WHO Western Pacific Region Medical Index (WPRIM), and the Chinese Science Citation Database (Core Database) (CSCD); it is a statistical source journal of Chinese scientific and technological papers, a Chinese core journal, and a "double-effect" journal of the Chinese Journal Matrix; it is the "2nd, 3rd, and 4th China University Excellent Science and Technology Journal", "2008 China Excellent Science and Technology Journal", "RCCSE China Authoritative Academic Journal (A+)" and Hunan Province's "Top Ten Science and Technology Journals". The purpose of the journal is to reflect the new achievements, new technologies, and new experiences in medical research, medical treatment, and teaching, report new medical trends at home and abroad, promote academic exchanges, improve academic standards, and promote scientific and technological progress.
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