钯催化的多组分[4+2]1,4 -炔与CO和芳胺环加成通过脱芳重排获得多环γ-内酰胺

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-01-22 DOI:10.1039/d4qo02304h

Qi Xue , Zheng-Li Fu , Wen-Yu Zhang , Xia-Lu Cheng , Yang Li , Hu Cai , Jin-Heng Li

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引用次数: 0

摘要

本文报道了一种新的钯催化1,4 -炔与CO和芳胺的分子间[4+2]环加成反应。与著名的Himbert分子内芳烃/烯环加成法相比，该方法通过一步合成4个新化学键（3个C-C键和1个C-N键），具有优异的官能团耐受性和较高的原子经济性，为合成多环γ-内酰胺提供了方便的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Palladium-catalyzed multicomponent [4 + 2] cycloaddition of 1,4-enynes with CO and arylamines to access polycyclic γ-lactams via dearomative rearrangement†

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Palladium-catalyzed multicomponent [4 + 2] cycloaddition of 1,4-enynes with CO and arylamines to access polycyclic γ-lactams via dearomative rearrangement†

Herein we report a palladium-catalyzed intermolecular dearomative [4 + 2] cycloaddition of 1,4-enynes with CO and arylamines. Compared with the well-known Himbert intramolecular arene/allene cycloaddition, this method provides a facile platform for the synthesis of polycyclic γ-lactams, through the formation of four new chemical bonds (three C–C bonds and one C–N bond) in a single step, with excellent functional-group tolerance and high atom-economy.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

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