有严重细支气管炎病史的6岁儿童3岁时维生素D状况与嗜酸性粒细胞性哮喘的关系

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2025-01-06 DOI:10.1136/thorax-2024-222099

George Doumat, Joumane El Zein, Geneva D Mehta, Zhaozhong Zhu, Janice A Espinola, Ashley F Sullivan, Kohei Hasegawa, Carlos A Camargo

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引用次数: 0

摘要

幼儿血清25-羟基维生素D （25(OH)D）与嗜酸性哮喘之间的关系尚不清楚。我们使用584例需要住院治疗的毛细支气管炎患儿（高危人群）的多中心前瞻性数据调查了这种关联。低血清25(OH)D水平（<20 ng/mL）与发生嗜酸性粒细胞哮喘的几率增加相关(调整OR为2.33；95% ci 1.23, 4.40；p=0.01)，与血清25(OH)D为20 ~ 39.9 ng/mL的儿童比较。我们的数据有助于进一步研究有严重细支气管炎和嗜酸性粒细胞增多病史的儿童在早期补充维生素D预防儿童哮喘的潜在作用。

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Association between vitamin D status at 3 years and eosinophilic asthma in 6-year-old children with a history of severe bronchiolitis

The association between early childhood serum 25-hydroxyvitamin D (25(OH)D) and eosinophilic asthma remains unclear. We investigated this association using multicentre prospective data from 584 children with a history of bronchiolitis requiring hospitalisation (high-risk population). Low serum 25(OH)D levels (<20 ng/mL) were associated with increased odds of developing eosinophilic asthma (adjusted OR 2.33; 95% CI 1.23, 4.40; p=0.01) as compared with children with serum 25(OH)D of 20–39.9 ng/mL. Our data facilitate further investigation into the potential role of early-life vitamin D supplementation among children with a history of severe bronchiolitis and eosinophilia for preventing childhood asthma.

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.