手性锰配合物介导的聚烯烃高位置和对映选择性催化环氧化反应，包括角鲨烯一步转化为天然甾体和萜类前体(S)-2,3-环氧化物

IF 15.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-01-06 DOI:10.1021/jacs.4c16570

G. Sudhakar Reddy, E. J. Corey

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引用次数: 0

摘要

本文报道了一种新的Mn（II）手性二羧基配体的合成，以及Mn配合物在温和条件下应用于C = C的高度对映和位置选择性环氧化反应，甚至使用聚烯烃底物。提出了不对称感应的立体力学基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Highly Position- and Enantioselective Catalytic Epoxidation of Polyolefins Mediated by a Chiral Mn Complex, Including a One-Step Conversion of Squalene to the (S)-2,3-Epoxide, a Precursor of Natural Steroids and Terpenoids

查看原文本刊更多论文

Reported herein is the synthesis of a novel chiral dicarboxylic ligand for Mn(II) and the application of the Mn complex to the highly enantio- and position-selective epoxidation of C═C under mild conditions, even with polyolefinic substrates. A stereomechanistic basis for asymmetric induction is suggested.

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.