Anish Mehta, Samuel Y E Ng, Shermyn X M Neo, Nicole S Y Chia, Ehsan S Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L Heng, Z Y Xu, K Y Tay, W L Au, E K Tan, Louis C S Tan
{"title":"COVID-19大流行期间社会隔离和帕金森病症状变化的评估：一项纵向研究","authors":"Anish Mehta, Samuel Y E Ng, Shermyn X M Neo, Nicole S Y Chia, Ehsan S Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L Heng, Z Y Xu, K Y Tay, W L Au, E K Tan, Louis C S Tan","doi":"10.1016/j.prdoa.2024.100293","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.</p><p><strong>Objective: </strong>This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).</p><p><strong>Methods: </strong>Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions. Individuals with LSNS-R scores ≤ 24 were considered socially isolated. Data were stratified into strata 1 (improved LSNS-R scores) and strata 2 (worsened/unchanged scores). Linear regression was used to identify predictors of LSNS-R change, and MANCOVA was used to examine associations between LSNS-R change and motor/ non-motor symptoms.</p><p><strong>Results: </strong>Mean LSNS-R scores decreased (p = 0.014), and proportions of social isolation increased (p < 0. 001) during COVID-19 restrictions. However, 35 % showed improved LSNS-R scores, while 65 % had worsened/unchanged scores. The regression model was significant in strata 1 (R2 = 0.806, p = 0.001), with age, marital status, and social isolation status being significantly associated with change in LSNS-R scores. LSNS-R. Results of MANCOVA indicated that LSNS-R improvements in LSNS-R were significantly associated with outcomes (Roy's Largest Root statistic = 126.638, p < 0.001), particularly for changes in PDQ8, HADS-Anxiety, and HADS-Depression scores. The regression model was not significant in strata 2 (R2 = 0. 279, p = 0.206), wherein motor and non-motor symptoms worsened.</p><p><strong>Conclusion: </strong>While worsening LSNS-R scores were associated with poorer outcomes, improvements in social networks were associated with improved non-motor symptoms and quality of life. These findings underscore the complexity of social isolation in PD and the need for targeted interventions.</p>","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"100293"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696853/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of social isolation and changes in Parkinson's disease symptoms during the COVID-19 pandemic: A longitudinal study.\",\"authors\":\"Anish Mehta, Samuel Y E Ng, Shermyn X M Neo, Nicole S Y Chia, Ehsan S Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L Heng, Z Y Xu, K Y Tay, W L Au, E K Tan, Louis C S Tan\",\"doi\":\"10.1016/j.prdoa.2024.100293\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.</p><p><strong>Objective: </strong>This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).</p><p><strong>Methods: </strong>Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions. Individuals with LSNS-R scores ≤ 24 were considered socially isolated. Data were stratified into strata 1 (improved LSNS-R scores) and strata 2 (worsened/unchanged scores). Linear regression was used to identify predictors of LSNS-R change, and MANCOVA was used to examine associations between LSNS-R change and motor/ non-motor symptoms.</p><p><strong>Results: </strong>Mean LSNS-R scores decreased (p = 0.014), and proportions of social isolation increased (p < 0. 001) during COVID-19 restrictions. However, 35 % showed improved LSNS-R scores, while 65 % had worsened/unchanged scores. The regression model was significant in strata 1 (R2 = 0.806, p = 0.001), with age, marital status, and social isolation status being significantly associated with change in LSNS-R scores. LSNS-R. Results of MANCOVA indicated that LSNS-R improvements in LSNS-R were significantly associated with outcomes (Roy's Largest Root statistic = 126.638, p < 0.001), particularly for changes in PDQ8, HADS-Anxiety, and HADS-Depression scores. The regression model was not significant in strata 2 (R2 = 0. 279, p = 0.206), wherein motor and non-motor symptoms worsened.</p><p><strong>Conclusion: </strong>While worsening LSNS-R scores were associated with poorer outcomes, improvements in social networks were associated with improved non-motor symptoms and quality of life. These findings underscore the complexity of social isolation in PD and the need for targeted interventions.</p>\",\"PeriodicalId\":33691,\"journal\":{\"name\":\"Clinical Parkinsonism Related Disorders\",\"volume\":\"12 \",\"pages\":\"100293\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-12-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696853/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Parkinsonism Related Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.prdoa.2024.100293\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Parkinsonism Related Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.prdoa.2024.100293","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Assessment of social isolation and changes in Parkinson's disease symptoms during the COVID-19 pandemic: A longitudinal study.
Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.
Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).
Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions. Individuals with LSNS-R scores ≤ 24 were considered socially isolated. Data were stratified into strata 1 (improved LSNS-R scores) and strata 2 (worsened/unchanged scores). Linear regression was used to identify predictors of LSNS-R change, and MANCOVA was used to examine associations between LSNS-R change and motor/ non-motor symptoms.
Results: Mean LSNS-R scores decreased (p = 0.014), and proportions of social isolation increased (p < 0. 001) during COVID-19 restrictions. However, 35 % showed improved LSNS-R scores, while 65 % had worsened/unchanged scores. The regression model was significant in strata 1 (R2 = 0.806, p = 0.001), with age, marital status, and social isolation status being significantly associated with change in LSNS-R scores. LSNS-R. Results of MANCOVA indicated that LSNS-R improvements in LSNS-R were significantly associated with outcomes (Roy's Largest Root statistic = 126.638, p < 0.001), particularly for changes in PDQ8, HADS-Anxiety, and HADS-Depression scores. The regression model was not significant in strata 2 (R2 = 0. 279, p = 0.206), wherein motor and non-motor symptoms worsened.
Conclusion: While worsening LSNS-R scores were associated with poorer outcomes, improvements in social networks were associated with improved non-motor symptoms and quality of life. These findings underscore the complexity of social isolation in PD and the need for targeted interventions.
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