在接受PTAS治疗的严重颅内动脉狭窄患者中，围治疗期动脉内血流变化可预测支架的长期通畅。

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-02-01 DOI:10.1016/j.ejrad.2024.111913

Feng-Chi Chang , Chia-Jen Wu , Kan Ling , Ting-Yi Chen , Jiing-Feng Lirng , Chia-Hung Wu

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引用次数: 0

摘要

背景与目的：经皮腔内血管成形术和支架植入术（PTAS）治疗严重颅内动脉狭窄后的定量动脉内血流动力学从未被研究过。我们的目的是通过定量磁共振血管造影（qMRA）评估PTAS后围治疗期颅内动脉血流动力学，以预测长期支架通畅。设计：这是一项前瞻性单中心研究。方法：我们招募了2018年至2022年期间颅内颈内动脉（ICA）至大脑中动脉（MCA） M1段严重症状性狭窄的参与者。术前、术后早期、术后12个月分别行qMRA，记录双侧M1段及基底动脉（BA）血流参数。校正后的M1比率以对侧M1 （cM1）和BA （cMB）流为参考计算。我们评估了有12个月支架内再狭窄（ISR）和没有明显再狭窄（ISR）受试者之间qMRA参数的差异。结果：纳入44例受试者（12例+ 32例，无ISR≥50%）。有ISR （p = 0.030）和无ISR （p = 0.031）的受试者术后早期M1流高于术前M1流。无ISR的患者术后早期健康侧M1血流明显低于术前（p = 0.014）。早期(p 2 = 0.190；p = 0.003)。结论：早期qMRA （PTAS后24小时内）的cM1和明显的血流动力学模式可以预测12个月的ISR。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Peritherapeutic intra-arterial flow changes predict long-term stent patency in patients with severe intracranial artery stenosis receiving PTAS

查看原文本刊更多论文

Peritherapeutic intra-arterial flow changes predict long-term stent patency in patients with severe intracranial artery stenosis receiving PTAS

Background and purpose

The quantitative intra-arterial flow dynamics following percutaneous transluminal angioplasty and stenting (PTAS) for severe intracranial artery stenosis have never been investigated. We aimed to evaluate peritherapeutic intracranial artery flow dynamics following PTAS with quantitative magnetic resonance angiography (qMRA) to predict long-term stent patency.

Design

This is a prospective, single-center study.

Methods

We recruited participants with severe symptomatic stenosis from intracranial internal carotid artery (ICA) to M1 segment of middle cerebral artery (MCA) between 2018 and 2022. qMRA was performed before (preprocedural), within 24 h after (early postprocedural) and 12 months after (delayed postprocedural) PTAS, and parameters including bilateral M1 segments and basilar artery (BA) flow were recorded. The calibrated M1 ratio was calculated using contralateral M1 (cM1) and BA (cMB) flows as references. We assessed differences in qMRA parameters between subjects with and without significant 12-month in-stent restenosis (ISR).

Results

Forty-four subjects (12 with + 32 without ISR ≥ 50 %) were included. The early postprocedural M1 flow was higher than preprocedural M1 flow in subjects with (p = 0.030) and without (p = 0.031) ISR. The early postprocedural healthy-side M1 flow was lower than preprocedural healthy-side M1 flow (p = 0.014) in subjects without ISR. Both the early (p < 0.001) and delayed (p = 0.014) cM1s were greater than the preprocedural cM1. The residual stenosis grade was positively correlated with delayed postprocedural cM1 in all subjects (r² = 0.190; p = 0.003).

Conclusions

The cM1 and a distinct flow dynamic pattern on early qMRA (within 24 h after PTAS) may predict 12-month ISR.

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.