成人尿中邻苯二甲酸酯和邻苯二甲酸酯替代代谢物与胆结石风险的关系:横断面分析

IF 3.2 3区 环境科学与生态学 Q3 ENGINEERING, ENVIRONMENTAL
Tianshan Shi, Di Li, Donghua Li, Peng Xie, Jin Sun, Tingrong Wang, Rui Li, Zixuan Zou, Zhenjuan Li, Xiaowei Ren
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引用次数: 0

摘要

目前尚不清楚邻苯二甲酸盐是否与胆结石有关,以及邻苯二甲酸盐替代品与胆结石的关系是否与传统的邻苯二甲酸盐不同。在这项研究中,来自NHANES 2017-2018的1735名参与者被纳入其中,他们的尿液被用来检测邻苯二甲酸酯代谢物。我们使用逻辑回归和限制三次样条回归来评估邻苯二甲酸酯代谢物与胆结石之间的个体关联和剂量-反应关系,分位g计算和贝叶斯核机回归来评估邻苯二甲酸酯代谢物与胆结石之间的混合关联,并使用亚组分析来探索潜在的效应修饰因子。我们观察到环己烷-1,2-二羧酸-邻苯二甲酸单(羧酸辛基)酯(mcchp) (OR: 1.423, 95% CI: 1.098-1.844)和环己烷-1,2-二羧酸单羟基异壬基酯(MHNCH) (OR: 1.380, 95% CI: 1.080-1.763)与胆结石的个体相关性呈线性正相关,邻苯二甲酸代谢物(OR: 2.453, 95% CI: 1.054-5.708)与胆结石的混合相关性也呈正相关,且MCOCHP和MHNCH的权重均为正相关。邻苯二甲酸酯代谢物与胆结石的相关性在男性和年龄≥60岁、BMI≥30 kg/m2、高血压和糖尿病的参与者中更高。MCOCHP和MHNCH的ppip最高(groupPIP: 0.941),邻苯二甲酸单(2-乙基-5-羧基戊二酯)(MECPTP)的condPIP最高(condPIP: 0.721),邻苯二甲酸单(2-乙基-5-羧基戊二酯)(MECPP)、MCOCHP和邻苯二甲酸单异丁酯(MiBP)的condPIP也很高(condPIP > 0.5)。邻苯二甲酸酯代谢物与胆结石的混合关联呈阳性趋势。我们的研究表明,传统的邻苯二甲酸盐和邻苯二甲酸盐替代品与胆结石有关,特别是在老年人、男性、肥胖人群、高血压人群和糖尿病人群中,邻苯二甲酸盐替代品与胆结石的高风险相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of phthalate and phthalate alternative metabolites in urine with the risk of gallstones in adults: a cross-sectional analysis.

It remains unclear whether phthalates are associated with gallstones and whether the associations of phthalate alternatives with gallstones are different from traditional phthalates. In this study, 1735 participants from the NHANES 2017-2018 were included and their urine was used to detect phthalate metabolites. We used logistic and restricted cubic spline regressions to assess individual associations and dose-response relationships between phthalate metabolites and gallstones, quantile g-computation and Bayesian kernel machine regression to assess mixed associations of phthalate metabolites with gallstones, and subgroup analyses to explore potential effect modifiers. We observed that individual associations of cyclohexane-1,2-dicarboxylic acid-mono(carboxyoctyl) ester phthalate (MCOCHP) (OR: 1.423, 95% CI: 1.098-1.844) and cyclohexane 1,2-dicarboxylic acid monohydroxy isononyl ester (MHNCH) (OR: 1.380, 95% CI: 1.080-1.763) with gallstones were linearly positive, mixed association of phthalate metabolites (OR: 2.453, 95% CI: 1.054-5.708) with gallstones was also positive, and MCOCHP and MHNCH had positive weights. The associations of phthalate metabolites with gallstones were higher in the males and participants with age ≥ 60 years, BMI ≥ 30 kg/m2, hypertension, and diabetes. MCOCHP and MHNCH had the highest groupPIP (groupPIP: 0.941), mono(2-ethyl-5-carboxypentyl) terephthalate (MECPTP) had the highest condPIP (condPIP: 0.721), and mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), MCOCHP, and mono-isobutyl phthalate (MiBP) also had high condPIPs (condPIP > 0.5). The trend in mixed associations of phthalate metabolites with gallstones was positive. Our study suggests that traditional phthalates and phthalate alternatives are associated with gallstones, especially in the elderly, men, obese, hypertensive populations, and diabetic populations, and phthalate alternatives are associated with a higher risk of gallstones.

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来源期刊
Environmental Geochemistry and Health
Environmental Geochemistry and Health 环境科学-工程:环境
CiteScore
8.00
自引率
4.80%
发文量
279
审稿时长
4.2 months
期刊介绍: Environmental Geochemistry and Health publishes original research papers and review papers across the broad field of environmental geochemistry. Environmental geochemistry and health establishes and explains links between the natural or disturbed chemical composition of the earth’s surface and the health of plants, animals and people. Beneficial elements regulate or promote enzymatic and hormonal activity whereas other elements may be toxic. Bedrock geochemistry controls the composition of soil and hence that of water and vegetation. Environmental issues, such as pollution, arising from the extraction and use of mineral resources, are discussed. The effects of contaminants introduced into the earth’s geochemical systems are examined. Geochemical surveys of soil, water and plants show how major and trace elements are distributed geographically. Associated epidemiological studies reveal the possibility of causal links between the natural or disturbed geochemical environment and disease. Experimental research illuminates the nature or consequences of natural or disturbed geochemical processes. The journal particularly welcomes novel research linking environmental geochemistry and health issues on such topics as: heavy metals (including mercury), persistent organic pollutants (POPs), and mixed chemicals emitted through human activities, such as uncontrolled recycling of electronic-waste; waste recycling; surface-atmospheric interaction processes (natural and anthropogenic emissions, vertical transport, deposition, and physical-chemical interaction) of gases and aerosols; phytoremediation/restoration of contaminated sites; food contamination and safety; environmental effects of medicines; effects and toxicity of mixed pollutants; speciation of heavy metals/metalloids; effects of mining; disturbed geochemistry from human behavior, natural or man-made hazards; particle and nanoparticle toxicology; risk and the vulnerability of populations, etc.
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