原发性肝细胞癌肉瘤：一个病例系列和文献综述。

IF 2.6 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Clinics and research in hepatology and gastroenterology Pub Date : 2025-02-01 DOI:10.1016/j.clinre.2024.102520

Haodong Qiao , Huaibin Guo , Ze Liang , Lin Kang , Wanxing Zhang

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引用次数: 0

摘要

肝细胞癌肉瘤（HCS）是一种罕见的侵袭性肝脏肿瘤，因其罕见而临床证据有限。本病例系列旨在丰富现有的HCS诊断和临床管理知识。方法：对4例HCS患者的症状、诊断、治疗及转归进行评价。我们还研究了HCS的影像学特征和肿瘤发生，强调了p53突变的作用。结果：本病例系列发现及时手术和局部化疗是治疗HCS的关键。尽管靶向治疗的结果很有希望，但在一些患者中发现了它的局限性。HCS的发生和发展与p53突变的存在显著相关。结论：本病例系列强调需要进一步研究以提高HCS的诊断和治疗，并强调及时手术和局部化疗对减轻肿瘤副作用和延长生存期的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Primary hepatocellular carcinosarcoma: A case series and literature review

Introduction

Hepatocellular carcinosarcoma (HCS) is a rare and aggressive liver tumor with limited clinical evidence due to its infrequency. This case series aimed to enrich the existing knowledge on the diagnosis and clinical management of HCS.

Methods

Four patients with HCS were evaluated, focusing on their symptoms, diagnoses, treatments, and outcomes. The imaging characteristics and tumorigenesis of HCS were also investigated, highlighting the role of p53 mutations.

Results

This case series found that timely surgery and localized chemotherapy are crucial in managing HCS. Despite the promising results of targeted therapy, its limitations were observed in some patients. The onset and progression of HCS were found to be significantly correlated with the presence of p53 mutations.

Conclusions

This case series underscores the need for further research to improve the diagnosis and treatment of HCS and emphasizes the importance of timely surgery and localized chemotherapy in mitigating tumor side effects and potentially prolonging survival.

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来源期刊

Clinics and research in hepatology and gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.30

自引率

3.70%

发文量

198

审稿时长

42 days

期刊介绍： Clinics and Research in Hepatology and Gastroenterology publishes high-quality original research papers in the field of hepatology and gastroenterology. The editors put the accent on rapid communication of new research and clinical developments and so called "hot topic" issues. Following a clear Editorial line, besides original articles and case reports, each issue features editorials, commentaries and reviews. The journal encourages research and discussion between all those involved in the specialty on an international level. All articles are peer reviewed by international experts, the articles in press are online and indexed in the international databases (Current Contents, Pubmed, Scopus, Science Direct). Clinics and Research in Hepatology and Gastroenterology is a subscription journal (with optional open access), which allows you to publish your research without any cost to you (unless you proactively chose the open access option). Your article will be available to all researchers around the globe whose institution has a subscription to the journal.