探索吖啶的治疗潜力：合成、结构和生物应用。

IF 4.5 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic Chemistry Pub Date : 2025-02-01 DOI:10.1016/j.bioorg.2024.108096

Diego Santa Clara Marques, Lisandra da Silva Lima, Josué Filipe de Oliveira Moraes Miranda, Carolina Ávila dos Anjos Santos, Iranildo José da Cruz Filho, Maria do Carmo Alves de Lima

{"title":"探索吖啶的治疗潜力：合成、结构和生物应用。","authors":"Diego Santa Clara Marques, Lisandra da Silva Lima, Josué Filipe de Oliveira Moraes Miranda, Carolina Ávila dos Anjos Santos, Iranildo José da Cruz Filho, Maria do Carmo Alves de Lima","doi":"10.1016/j.bioorg.2024.108096","DOIUrl":null,"url":null,"abstract":"<div><div>The objective of this review was to explore the trends and chemical characteristics of acridines and their derivatives, analyze their contribution to the scientific literature and international cooperation, identify the most influential authors and articles, and provide an overview of the knowledge produced in elucidating their mechanisms of action. To this end, a bibliometric analysis was performed using RStudio software, along with a systematic review focusing on articles indexed in the “Web of Science” and “Scopus” databases. The keywords used were “acridine$”, “Synthesi$”, “Structure$”, and “Biologic* Application$” for the period from 2020 to 2024. Relevant articles were carefully selected from these databases, and a bibliometric analysis was carried out to comprehensively discuss the most relevant biological activities associated with acridines. The results showed that, during the analyzed period, China and India led in the number of publications, followed by Brazil in third place. However, a decline in the number of publications was observed in the last two years of the period. Keyword analysis revealed that antitumor activity remains the most extensively studied aspect of acridines and their derivatives.</div></div>","PeriodicalId":257,"journal":{"name":"Bioorganic Chemistry","volume":"155 ","pages":"Article 108096"},"PeriodicalIF":4.5000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the therapeutic potential of acridines: Synthesis, structure, and biological applications\",\"authors\":\"Diego Santa Clara Marques, Lisandra da Silva Lima, Josué Filipe de Oliveira Moraes Miranda, Carolina Ávila dos Anjos Santos, Iranildo José da Cruz Filho, Maria do Carmo Alves de Lima\",\"doi\":\"10.1016/j.bioorg.2024.108096\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The objective of this review was to explore the trends and chemical characteristics of acridines and their derivatives, analyze their contribution to the scientific literature and international cooperation, identify the most influential authors and articles, and provide an overview of the knowledge produced in elucidating their mechanisms of action. To this end, a bibliometric analysis was performed using RStudio software, along with a systematic review focusing on articles indexed in the “Web of Science” and “Scopus” databases. The keywords used were “acridine$”, “Synthesi$”, “Structure$”, and “Biologic* Application$” for the period from 2020 to 2024. Relevant articles were carefully selected from these databases, and a bibliometric analysis was carried out to comprehensively discuss the most relevant biological activities associated with acridines. The results showed that, during the analyzed period, China and India led in the number of publications, followed by Brazil in third place. However, a decline in the number of publications was observed in the last two years of the period. Keyword analysis revealed that antitumor activity remains the most extensively studied aspect of acridines and their derivatives.</div></div>\",\"PeriodicalId\":257,\"journal\":{\"name\":\"Bioorganic Chemistry\",\"volume\":\"155 \",\"pages\":\"Article 108096\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioorganic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0045206824010010\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0045206824010010","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

本综述的目的是探讨吖啶及其衍生物的发展趋势和化学特性，分析其对科学文献和国际合作的贡献，确定最具影响力的作者和文章，并概述在阐明其作用机制方面所产生的知识。为此，使用RStudio软件进行了文献计量学分析，并对“Web of Science”和“Scopus”数据库中索引的文章进行了系统回顾。关键词为“吖啶$”、“合成$”、“结构$”和“生物*应用$”，时间为2020年至2024年。从这些数据库中精心挑选相关文章，进行文献计量学分析，全面探讨与吖啶相关的最相关的生物活性。结果显示，在分析期间，中国和印度的出版物数量最多，其次是巴西，排名第三。但是，在这一期间的最后两年，出版物的数量有所减少。关键词分析表明，抗肿瘤活性是吖啶类化合物及其衍生物研究最为广泛的方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Exploring the therapeutic potential of acridines: Synthesis, structure, and biological applications

查看原文本刊更多论文

Exploring the therapeutic potential of acridines: Synthesis, structure, and biological applications

The objective of this review was to explore the trends and chemical characteristics of acridines and their derivatives, analyze their contribution to the scientific literature and international cooperation, identify the most influential authors and articles, and provide an overview of the knowledge produced in elucidating their mechanisms of action. To this end, a bibliometric analysis was performed using RStudio software, along with a systematic review focusing on articles indexed in the “Web of Science” and “Scopus” databases. The keywords used were “acridine$”, “Synthesi$”, “Structure$”, and “Biologic* Application$” for the period from 2020 to 2024. Relevant articles were carefully selected from these databases, and a bibliometric analysis was carried out to comprehensively discuss the most relevant biological activities associated with acridines. The results showed that, during the analyzed period, China and India led in the number of publications, followed by Brazil in third place. However, a decline in the number of publications was observed in the last two years of the period. Keyword analysis revealed that antitumor activity remains the most extensively studied aspect of acridines and their derivatives.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Bioorganic Chemistry 生物-生化与分子生物学

CiteScore

9.70

自引率

3.90%

发文量

679

审稿时长

31 days

期刊介绍： Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry. For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature. The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.