慢性髓性白血病患者达沙替尼诱导结肠炎1例。

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

BMJ Case Reports Pub Date : 2025-01-04 DOI:10.1136/bcr-2024-263646

Alexander Edmund Gluch, Deloshaan Subhaharan, Sooraj Pillai, Pradeep Kakkadasam Ramaswamy

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引用次数: 0

摘要

达沙替尼是慢性髓性白血病的常用治疗方法，有许多副作用，包括胃肠道。我们报告了一位50多岁的女性，她表现为赤血病，体重减轻和粪便隐血试验阳性。她正在用达沙替尼治疗慢性髓性白血病，没有同时使用任何药物，包括非甾体抗炎药。最初的结肠镜检查显示中度斑片状左侧炎症，活检显示轻度慢性炎症和明显的嗜酸性粒细胞增多。随后停用达沙替尼，3个月后再次进行结肠镜检查，内窥镜和组织学显示炎症完全消退。

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Dasatinib-induced colitis in a patient with chronic myeloid leukaemia.

Dasatinib is a common treatment for chronic myeloid leukaemia with numerous side effects including gastrointestinal. We report a woman in her 50s who presented with haematochezia, weight loss and a positive faecal occult blood test. She was being treated for chronic myeloid leukaemia with dasatinib without the use of any concurrent medications, including non-steroidal anti-inflammatory drugs. Initial colonoscopy demonstrated moderate patchy left-sided inflammation, with biopsies revealing mild chronic inflammation and prominent eosinophilia. Dasatinib was subsequently ceased, and a repeat colonoscopy 3 months later demonstrated completely resolved inflammation both endoscopically and histologically.

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来源期刊

BMJ Case Reports Medicine-Medicine (all)

CiteScore

1.40

自引率

0.00%

发文量

1588

期刊介绍： BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.