解码蛋白质甲基组：鉴定，验证和功能见解。

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2025-02-01 DOI:10.1016/j.bmc.2024.118056

Ying Meng, Rong Huang

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引用次数: 0

摘要

蛋白质甲基化调节多种细胞过程，包括基因表达和DNA修复。本文综述了蛋白质甲基转移酶（MTases）底物的鉴定和验证方法，以及甲基化的生物学作用。同时，我们概述了全面绘制mase -底物对和揭示蛋白质甲基化在细胞功能中的复杂调节作用所需要的持续努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Decoding the protein methylome: Identification, validation, and functional insights

查看原文本刊更多论文

Decoding the protein methylome: Identification, validation, and functional insights

Protein methylation regulates diverse cellular processes including gene expression and DNA repair. This review discusses the methods of identifying and validating substrates for protein methyltransferases (MTases), as well as the biological roles of methylation. Meanwhile, we outline continued efforts necessary to fully map MTase-substrate pairs and uncover the complex regulatory roles of protein methylation in cellular function.

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.