CYP2C19多态性在症状性颅内动脉粥样硬化患者中的患病率

IF 2 Q3 PERIPHERAL VASCULAR DISEASE

Cerebrovascular Diseases Extra Pub Date : 2025-01-01 Epub Date: 2025-01-02 DOI:10.1159/000543331

Songchai Kittipanprayoon, Pongpat Vorasayan, Aurauma Chutinet, Pajaree Chariyavilaskul, Nijasri C Suwanwela

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引用次数: 0

摘要

氯吡格雷联合阿司匹林治疗症状性颅内狭窄已被证明是有益的。CYP2C19多态性（CYP2C19*1、CYP2C19*2、CYP2C19*3、CYP2C19*17等位基因）影响氯吡格雷的疗效。尽管在泰国人群中进行了CYP2C19多态性的流行病学研究，但缺乏泰国症状性颅内狭窄患者CYP2C19等位基因变异频率的数据。本研究旨在确定CYP2C19多态性在症状性颅内狭窄患者中的患病率。方法：研究纳入100例泰国症状性颅内狭窄患者。采用实时聚合酶链式反应（rt-PCR）技术对CYP2C19等位基因（CYP2C19*1、CYP2C19*2、CYP2C19*3、CYP2C19*17）进行分型。结果：CYP2C19*1、CYP2C19*2、CYP2C19*3、CYP2C19*17等位基因频率分别为70.5%、26%、2.5%、1%。结果显示，有症状的颅内狭窄患者中，正常代谢者占53%，中间代谢者占36%，差代谢者占10%。结论：几乎一半的泰国症状性颅内狭窄患者是中度或低代谢。阿司匹林和氯吡格雷联用可能对这组患者无效。

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The Prevalence of CYP2C19 Polymorphism in Patients with Symptomatic Intracranial Atherosclerosis.

Introduction: Clopidogrel and aspirin were proved to have benefit in symptomatic intracranial stenosis. CYP2C19 polymorphism (CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles) affects efficacy of clopidogrel. Epidemiologic study of CYP2C19 polymorphism has been conducted in Thai population. There was no data showed the frequency of allelic variants of CYP2C19 in Thai symptomatic intracranial stenosis patients. The aim of this study was to determine the prevalence of CYP2C19 polymorphism in symptomatic intracranial stenosis patients.

Methods: The study group included 100 Thai symptomatic intracranial stenosis patients. Genotyping of CYP2C19 alleles (CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles) was carried out by real-time polymerase chain reaction (rt-PCR) technique.

Results: The allele frequency of CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 were 70.5%, 26%, 2.5%, and 1%, respectively. The result showed that 53% of symptomatic intracranial stenosis patients are normal metabolizers, while intermediate and poor metabolizer were 36 and 10 percent, respectively.

Conclusion: Almost one-half of Thai symptomatic intracranial stenosis patients were intermediate or poor metabolizers. Usage of combination of aspirin and clopidogrel might not be effective in this group of patients.

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来源期刊

Cerebrovascular Diseases Extra PERIPHERAL VASCULAR DISEASE-

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： This open access and online-only journal publishes original articles covering the entire spectrum of stroke and cerebrovascular research, drawing from a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. Offering an international forum, it meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues. The journal publishes original contributions, reviews of selected topics as well as clinical investigative studies. All aspects related to clinical advances are considered, while purely experimental work appears only if directly relevant to clinical issues. Cerebrovascular Diseases Extra provides additional contents based on reviewed and accepted submissions to the main journal Cerebrovascular Diseases.