Xiaojun Hao, Chao Zhang, Chen Yang, Xintong Zhao, Yunfeng Zhou, Juan Wang
{"title":"介绍一种利用烟雾病术前CT灌注参数预测血运重建后脑梗死的指标。","authors":"Xiaojun Hao, Chao Zhang, Chen Yang, Xintong Zhao, Yunfeng Zhou, Juan Wang","doi":"10.1186/s13244-024-01882-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD).</p><p><strong>Methods: </strong>This retrospective study included 92 adults with MMD who underwent surgical revascularization. Preoperative quantitative CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to drain (TTD), and transit time to maximum of the residue function (Tmax), along with clinical data, were compared between the groups with and without post-CI. Predictors of post-CI were identified and assessed using multivariable logistic regression and receiver-operating characteristic curve analyses.</p><p><strong>Results: </strong>Post-CI occurred in 11 patients (12.0%). In univariate analysis, preoperative mean values for CBF, MTT, TTD, Tmax, initial presentation, infarction within the 2 months before surgery, surgical side, and modified Rankin Scale score on admission were associated with post-CI (all p < 0.05). Multivariable logistic regression revealed that the preoperative mean Tmax (OR 2.342, 95% CI: 1.267-4.330, p = 0.007) and infarction within the 2 months before surgery (OR 14.345, 95% CI: 2.108-97.638, p = 0.006) were independent predictors of post-CI. The preoperative mean Tmax produced the largest area under the curve (0.955, 95% CI: 0.914-0.997) with a cutoff of 3.590 s (sensitivity, 100%; specificity, 87.7%).</p><p><strong>Conclusions: </strong>Adults with MMD are at risk of post-CI when the preoperative mean Tmax is > 3.590 s. Cerebral infarction during the 2 months before revascularization is also a risk factor for post-CI.</p><p><strong>Critical relevance statement: </strong>Post-CI is a serious complication for adults with MMD following surgical revascularization. The risk of post-CI can be predicted using preoperative CTP parameters, which will assist neurosurgeons with surgical decisions and implementing individualized prophylactic strategies.</p><p><strong>Key points: </strong>Predicting the risk of post-CI in MMD patients is beneficial to their prognosis. The preoperative mean Tmax was an excellent perfusion parameter for predicting post-CI. Preoperative CTP evaluation can help clinicians make cautious surgical decisions.</p>","PeriodicalId":13639,"journal":{"name":"Insights into Imaging","volume":"16 1","pages":"2"},"PeriodicalIF":4.1000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695507/pdf/","citationCount":"0","resultStr":"{\"title\":\"Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease.\",\"authors\":\"Xiaojun Hao, Chao Zhang, Chen Yang, Xintong Zhao, Yunfeng Zhou, Juan Wang\",\"doi\":\"10.1186/s13244-024-01882-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD).</p><p><strong>Methods: </strong>This retrospective study included 92 adults with MMD who underwent surgical revascularization. Preoperative quantitative CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to drain (TTD), and transit time to maximum of the residue function (Tmax), along with clinical data, were compared between the groups with and without post-CI. Predictors of post-CI were identified and assessed using multivariable logistic regression and receiver-operating characteristic curve analyses.</p><p><strong>Results: </strong>Post-CI occurred in 11 patients (12.0%). In univariate analysis, preoperative mean values for CBF, MTT, TTD, Tmax, initial presentation, infarction within the 2 months before surgery, surgical side, and modified Rankin Scale score on admission were associated with post-CI (all p < 0.05). Multivariable logistic regression revealed that the preoperative mean Tmax (OR 2.342, 95% CI: 1.267-4.330, p = 0.007) and infarction within the 2 months before surgery (OR 14.345, 95% CI: 2.108-97.638, p = 0.006) were independent predictors of post-CI. The preoperative mean Tmax produced the largest area under the curve (0.955, 95% CI: 0.914-0.997) with a cutoff of 3.590 s (sensitivity, 100%; specificity, 87.7%).</p><p><strong>Conclusions: </strong>Adults with MMD are at risk of post-CI when the preoperative mean Tmax is > 3.590 s. Cerebral infarction during the 2 months before revascularization is also a risk factor for post-CI.</p><p><strong>Critical relevance statement: </strong>Post-CI is a serious complication for adults with MMD following surgical revascularization. The risk of post-CI can be predicted using preoperative CTP parameters, which will assist neurosurgeons with surgical decisions and implementing individualized prophylactic strategies.</p><p><strong>Key points: </strong>Predicting the risk of post-CI in MMD patients is beneficial to their prognosis. The preoperative mean Tmax was an excellent perfusion parameter for predicting post-CI. 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Introducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease.
Objective: To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD).
Methods: This retrospective study included 92 adults with MMD who underwent surgical revascularization. Preoperative quantitative CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to drain (TTD), and transit time to maximum of the residue function (Tmax), along with clinical data, were compared between the groups with and without post-CI. Predictors of post-CI were identified and assessed using multivariable logistic regression and receiver-operating characteristic curve analyses.
Results: Post-CI occurred in 11 patients (12.0%). In univariate analysis, preoperative mean values for CBF, MTT, TTD, Tmax, initial presentation, infarction within the 2 months before surgery, surgical side, and modified Rankin Scale score on admission were associated with post-CI (all p < 0.05). Multivariable logistic regression revealed that the preoperative mean Tmax (OR 2.342, 95% CI: 1.267-4.330, p = 0.007) and infarction within the 2 months before surgery (OR 14.345, 95% CI: 2.108-97.638, p = 0.006) were independent predictors of post-CI. The preoperative mean Tmax produced the largest area under the curve (0.955, 95% CI: 0.914-0.997) with a cutoff of 3.590 s (sensitivity, 100%; specificity, 87.7%).
Conclusions: Adults with MMD are at risk of post-CI when the preoperative mean Tmax is > 3.590 s. Cerebral infarction during the 2 months before revascularization is also a risk factor for post-CI.
Critical relevance statement: Post-CI is a serious complication for adults with MMD following surgical revascularization. The risk of post-CI can be predicted using preoperative CTP parameters, which will assist neurosurgeons with surgical decisions and implementing individualized prophylactic strategies.
Key points: Predicting the risk of post-CI in MMD patients is beneficial to their prognosis. The preoperative mean Tmax was an excellent perfusion parameter for predicting post-CI. Preoperative CTP evaluation can help clinicians make cautious surgical decisions.
期刊介绍：
Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere!
I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe.
Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy.
A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field.
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The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members.
The journal went open access in 2012, which means that all articles published since then are freely available online.
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