肾细胞癌中泛素化修饰的失调。

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2024-12-19 eCollection Date: 2024-01-01 DOI:10.3389/fgene.2024.1453191

Hongjie You, Hui Zhang, Xiaofeng Jin, Zejun Yan

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引用次数: 0

摘要

肾细胞癌（RCC）是肾小管上皮细胞的恶性肿瘤，在全球发病率较高。大量研究表明，泛素化失调（包括泛素化和失调）与 RCC 的发生和发展有关。本综述重点讨论由E3连接酶和去泛素化酶引起的几种异常信号通路。此外，我们还讨论了通过靶向泛素化修饰相关的关键酶来治疗 RCC 的研究进展。

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Dysregulation of ubiquitination modification in renal cell carcinoma.

Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases. Additionally, we discuss research progress in RCC treatment by targeting key enzymes related to ubiquitination modifications.

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.