Outcomes of Optical Coherence Tomography-Guided and Angiography-Guided Primary Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction.

Background: Despite the administration of timely reperfusion treatment, patients with acute myocardial infarction have a high mortality rate and poor prognosis. The potential impact of intraluminal imaging guidance, such as optical coherence tomography (OCT), on improving patient outcomes has yet to be conclusively studied. Therefore, we conducted a retrospective cohort study to compare OCT-guided primary percutaneous coronary intervention (PCI) versus angiography-guided for patients with ST-segment elevation myocardial infarction (STEMI).

Methods: This study enrolled 1396 patients with STEMI who underwent PCI, including 553 patients who underwent OCT-guided PCI and 843 patients who underwent angiography-guided PCI. The clinical outcome was a composite of cardiovascular death, myocardial infarction, admission due to heart failure, stroke, and unplanned revascularization at the 4-year follow-up.

Results: The prevalence of major adverse cardiovascular events in OCT-guided group was not significantly lower compared to those without OCT guidance after adjustment (unadjusted hazard ratio (HR), 1.582; 95% confidence interval (CI), 1.300-1.924; p < 0.001; adjusted HR, 1.095; adjusted 95% CI, 0.883-1.358; p = 0.409). The prevalence of cardiovascular death was significantly lower in patients with OCT guidance compared to those without before and after adjustment (unadjusted HR, 3.303; 95% CI, 2.142-5.093; p < 0.001; adjusted HR, 2.025; adjusted 95% CI, 1.225-3.136; p = 0.004).

Conclusions: OCT-guided primary PCI used to treat STEMI was associated with reduced long-term cardiovascular death.