肠道微生物群在化疗性腹泻及其治疗中的重要作用。

IF 3.3 3区医学 Q2 ONCOLOGY

Journal of Cancer Pub Date : 2025-01-01 DOI:10.7150/jca.99421

Wanrou Jiang, Yongjun Wu, Xiuyun He, Ling Jiang, Wanyi Zhang, Wenjuan Zheng, Min Hu, Chaofu Zhu

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引用次数: 0

摘要

化疗引起的腹泻（CID）是化疗常见的有害副作用，严重影响患者的生活质量，并可能危及患者的生存机会。肠道菌群平衡的破坏和肠道屏障的完整性受损是导致黏膜炎引起CID的关键因素。本文通过研究肠道菌群激活toll样受体和STING通路介导肠道免疫应答引起的肠黏膜炎症的机制，揭示了肠道菌群在化疗性腹泻中的新机制，为CID的预防和管理提供了创新途径。

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Important Role of Intestinal Microbiota in Chemotherapy-induced Diarrhea and Therapeutics.

Chemotherapy-induced diarrhea (CID) is a common and harmful side effect of chemotherapy, greatly impacting patients' quality of life and potentially compromising their chances of survival. Disruption of the balance in intestinal microbiota and compromised integrity of the intestinal barrier are key factors contributing to CID caused by mucositis. This paper investigated the mechanism through which intestinal microbiota activate Toll-like receptors and STING pathways to mediate intestinal mucosal inflammation resulting from immune responses in the gut, uncovering a novel mechanism of intestinal microbiota in chemotherapy-induced diarrhea, and suggesting innovative approaches for the prevention and management of CID.

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来源期刊

Journal of Cancer ONCOLOGY-

CiteScore

8.10

自引率

2.60%

发文量

333

审稿时长

12 weeks

期刊介绍： Journal of Cancer is an open access, peer-reviewed journal with broad scope covering all areas of cancer research, especially novel concepts, new methods, new regimens, new therapeutic agents, and alternative approaches for early detection and intervention of cancer. The Journal is supported by an international editorial board consisting of a distinguished team of cancer researchers. Journal of Cancer aims at rapid publication of high quality results in cancer research while maintaining rigorous peer-review process.