南极真菌ochraceopaliformis SCSIO 05702的4个笼化螺环酰胺的抗rsv活性[5,6,5]

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-01-02 DOI:10.1021/acs.orglett.4c04371

Mengjing Cong, Yinyan Li, Yanqin Li, Xiangliu Chen, Xiaoyan Pang, Yan Yan, Xinpeng Tian, Yonghong Liu, Jie Yang, Junfeng Wang

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引用次数: 0

摘要

从南极真菌曲霉（Aspergillus ochraceopaliformis SCSIO 05702）中分离得到四种未描述的螺环酰胺。通过光谱分析和量子计算阐明了它们的结构。螺环酰胺a - d具有罕见报道的笼状5/6/5融合螺环酰胺支架。螺旋藻蛋白酶B通过靶向病毒进入期和抑制病毒吸附来发挥抗病毒作用。值得注意的是，表面等离子体共振（SPR）显示2与RSV-G蛋白有很强的结合亲和力，KD值为7.95 nM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Spirochrains A–D, Four Caged [5,6,5] Spirocyclic Amides from an Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702 with Anti-RSV Activities

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Spirochrains A–D, Four Caged [5,6,5] Spirocyclic Amides from an Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702 with Anti-RSV Activities

Spirochrains A–D, four undescribed spirocyclic amides, were obtained from an Antarctic fungus, Aspergillus ochraceopetaliformis SCSIO 05702. Their structures were elucidated through spectroscopic analysis and quantum calculations. Spirochrains A–D possess a rarely reported cage-like 5/6/5 fused spirocyclic amide scaffold. Spirochrain B exerted antiviral effects by targeting the viral entry phase and inhibiting viral adsorption. Noteworthily, surface plasmon resonance (SPR) revealed strong binding affinity of 2 to RSV-G protein with a K_D value of 7.95 nM.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.