什么是QSP，它为什么存在？：简史。

Q1 Pharmacology, Toxicology and Pharmaceutics

Handbook of experimental pharmacology Pub Date : 2024-12-31 DOI:10.1007/164_2024_733

Christina Friedrich

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引用次数: 0

摘要

定量系统药理学（QSP）是一种用于药物研究和开发的建模方法，它将生物过程的机制表示与药物药理学相结合，以加深对生物学的理解并预测对新药物或方案的反应。QSP是从其他建模方法演变而来的，并且与之相关，但是有许多独特的属性和应用程序。本文阐明了QSP的定义及其主要特征，追溯了QSP的发展历程，简要地将其与其他方法进行了比较，并解释了为什么以及如何使用QSP来降低药物研发的风险和提高效率。

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What Is QSP and Why Does It Exist?: A Brief History.

Quantitative systems pharmacology (QSP) is a modeling approach employed in drug research and development that combines mechanistic representations of biological processes with drug pharmacology to deepen biological understanding and predict the responses to novel drugs or protocols. QSP has evolved from and is related to other modeling approaches, but has a number of unique attributes and applications. Here, we clarify the definition of QSP and its key features, trace its evolution, briefly compare it to other approaches, and explain why and how it can be used to reduce risk and improve efficiency in drug research and development.

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来源期刊

Handbook of experimental pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

5.20

自引率

0.00%

发文量

期刊介绍： The Handbook of Experimental Pharmacology is one of the most authoritative and influential book series in pharmacology. It provides critical and comprehensive discussions of the most significant areas of pharmacological research, written by leading international authorities. Each volume in the series represents the most informative and contemporary account of its subject available, making it an unrivalled reference source.