胰腺癌的代谢可塑性：线粒体连接。

IF 7 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Molecular Metabolism Pub Date : 2025-02-01 DOI:10.1016/j.molmet.2024.102089

Noemi Ghiglione , Damiano Abbo , Anastasia Bushunova , Andrea Costamagna, Paolo Ettore Porporato, Miriam Martini

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引用次数: 0

摘要

细胞代谢在胰腺导管腺癌（PDAC）的发生和发展中起着关键作用，代谢途径失调导致肿瘤发生和治疗抵抗。胰腺癌存在明显的代谢异质性，影响患者预后，因为代谢谱的变化会影响肿瘤行为和治疗反应。在这里，我们回顾了线粒体动力学、线粒体自噬和PDAC细胞代谢之间复杂的相互作用。我们强调了线粒体自噬失调在PDAC发病机制、影响治疗反应和预后中的重要意义。此外，我们研究了线粒体动力学改变对PDAC进展的影响，重点关注了裂变和融合过程在肿瘤发生中的作用。正在进行的试验已经证明了靶向线粒体动力学和线粒体自噬的关键调节因子的潜在治疗价值。尽管存在挑战，但靶向线粒体代谢提供了多种策略来提高PDAC的治疗效果，强调了其在推进癌症治疗方面的潜力。

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Metabolic plasticity in pancreatic cancer: The mitochondrial connection

Background

Cellular metabolism plays a pivotal role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), with dysregulated metabolic pathways contributing to tumorigenesis and therapeutic resistance. Distinct metabolic heterogeneity in pancreatic cancer significantly impacts patient prognosis, as variations in metabolic profiles influence tumor behavior and treatment responses.

Scope of the Review: This review explores the intricate interplay between mitochondrial dynamics, mitophagy, and cellular metabolism in PDAC. We discuss the significance of mitophagy dysregulation in PDAC pathogenesis, emphasizing its influence on treatment responses and prognosis. Furthermore, we analyze the impact of mitochondrial dynamics alterations, including fission and fusion processes, on PDAC progression and tumorigenesis.

Major Conclusion

Targeting mitochondrial metabolism holds promise for advancing PDAC therapeutics. Ongoing clinical trials underscore the therapeutic potential of modulating key regulators of mitochondrial dynamics and mitophagy. Despite inherent challenges, these approaches offer diverse strategies to enhance treatment efficacy and improve patient outcomes.

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来源期刊

Molecular Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

14.50

自引率

2.50%

发文量

219

审稿时长

43 days

期刊介绍： Molecular Metabolism is a leading journal dedicated to sharing groundbreaking discoveries in the field of energy homeostasis and the underlying factors of metabolic disorders. These disorders include obesity, diabetes, cardiovascular disease, and cancer. Our journal focuses on publishing research driven by hypotheses and conducted to the highest standards, aiming to provide a mechanistic understanding of energy homeostasis-related behavior, physiology, and dysfunction. We promote interdisciplinary science, covering a broad range of approaches from molecules to humans throughout the lifespan. Our goal is to contribute to transformative research in metabolism, which has the potential to revolutionize the field. By enabling progress in the prognosis, prevention, and ultimately the cure of metabolic disorders and their long-term complications, our journal seeks to better the future of health and well-being.