LMCT-Homolysis-Enabled C−H功能化芳胺

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-01-08 DOI:10.1039/d4qo02146k

Qiping He , Wenxin Yan , Xianglin Yu , Xinxiang Huang , Chang Liu , Yinchun Jiao , Yi Jin

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引用次数: 0

摘要

本文报道了一种通过光诱导配体到金属电荷转移（LMCT）实现芳胺金属催化的对csp2−H功能化的方法。光- lmct均解模式允许Sc−N配合物形成氮自由基中间体，然后被异构化为芳基自由基并为后续的自由基偶联做准备。C−O、C−S、C−Se和C−C键的选择性构建已经实现，这些反应提供了操作简单、低催化剂和高度区域选择性的过程，可以在一个步骤中获得有价值的芳胺功能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

LMCT–homolysis-enabled C–H functionalization of arylamines†

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LMCT–homolysis-enabled C–H functionalization of arylamines†

Herein, we report a method for metal-catalyzed para-Csp²–H functionalization of arylamines through photoinduced ligand-to-metal charge transfer (LMCT) for prospective application. The photo-LMCT–homolysis mode allows Sc–N complexes to form nitrogen radical intermediates, which are then isomerized into aryl radicals and prepared for subsequent radical coupling. A selective construction of C–O, C–S, C–Se, and C–C bonds has been achieved, and these reactions offer operationally simple, low-catalyst, and highly regioselective procedures for accessing valuable arylamine functionalization in a single step.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量