评估妊娠中期母体脂质对胎儿心功能的影响:一项观察性研究。

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Biliana Belovan, Zoran Laurentiu Popa, Cosmin Citu, Ioana Mihaela Citu, Ioan Sas, Adrian Ratiu
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引用次数: 0

摘要

背景:妊娠期母亲血脂异常可能影响胎儿心脏发育和功能,潜在地使后代在以后的生活中易患心血管疾病。本研究旨在利用详细的超声心动图评估妊娠中期母体脂质谱与胎儿心功能之间的关系。方法:在Timișoara市急诊医院妇产科门诊进行的前瞻性队列研究中,招募了19名年龄在27-40岁之间的孕妇,并根据其甘油三酯水平分为两组:A组(甘油三酯≤150mg /dL, n = 48)和B组(甘油三酯≤150mg /dL, n = 28)。记录产妇人口统计数据和血脂。胎儿超声心动图测量,包括整体纵向应变和心室功能参数,在妊娠20至24周期间获得。进行统计分析,包括亚组比较、相关性和回归分析。结果:B组产妇BMI明显高于A组(31.94±2.80 vs. 27.01±2.40 kg/m2, p < 0.001)。B组甘油三酯水平(163.43±11.34 mg/dL)高于A组(131.42±10.57 mg/dL, p < 0.001)。胎儿超声心动图测量显示,B组母亲的胎儿整体纵向应变降低(LV应变:-19.86%±6.83% vs -26.14%±5.92%,p = 0.017)。母体甘油三酯水平与胎儿LV株有显著相关性(r = 0.536, p = 0.019)。回归分析发现,母体甘油三酯水平和BMI是胎儿LV菌株减少的显著预测因子(β = 0.45, p = 0.021和β = 0.39, p = 0.038)。结论:母体甘油三酯水平、低密度脂蛋白胆固醇和BMI升高与妊娠中期胎儿心功能参数改变有关,提示母体脂质谱可能影响胎儿心脏发育。这些发现强调了监测妊娠期间血脂水平的重要性,并提示控制血脂异常对改善胎儿心脏结局的潜在益处。然而,这项研究只包括了一个小样本;因此,这项研究需要在更大的群体中继续进行。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the Impact of Maternal Lipid Profiles on Fetal Cardiac Function at Mid-Gestation: An Observational Study.

Background: Maternal dyslipidemia during pregnancy may influence fetal cardiac development and function, potentially predisposing offspring to cardiovascular diseases later in life. This study aims to evaluate the relationship between maternal lipid profiles and fetal cardiac function at mid-gestation, utilizing detailed echocardiographic assessments. Methods: In this prospective cohort study conducted at the Obstetrics and Gynecology Clinic of the Timișoara Municipal Emergency Hospital, 19 pregnant women aged 27-40 years were recruited and divided into two groups based on their triglyceride levels: Group A (triglycerides ≤ 150 mg/dL, n = 48) and Group B (triglycerides > 150 mg/dL, n = 28). Maternal demographic data and lipid profiles were recorded. Fetal echocardiographic measurements, including global longitudinal strain and ventricular function parameters, were obtained between 20 and 24 weeks of gestation. Statistical analyses, including subgroup comparisons, correlations, and regression analyses, were performed. Results: Maternal BMI was significantly higher in Group B compared to Group A (31.94 ± 2.80 vs. 27.01 ± 2.40 kg/m2, p < 0.001). Group B showed higher mean triglyceride levels (163.43 ± 11.34 mg/dL) compared to Group A (131.42 ± 10.57 mg/dL, p < 0.001). Fetal echocardiographic measurements indicated reduced global longitudinal strain in fetuses of Group B mothers (LV strain: -19.86% ± 6.83% vs. -26.14% ± 5.92%, p = 0.017). Significant correlations were found between maternal triglyceride levels and fetal LV strain (r = 0.536, p = 0.019). Regression analysis identified maternal triglyceride levels and BMI as significant predictors of reduced fetal LV strain (β = 0.45, p = 0.021 and β = 0.39, p = 0.038, respectively). Conclusions: Elevated maternal triglyceride levels, LDL cholesterol, and BMI are associated with altered fetal cardiac function parameters at mid-gestation, suggesting that maternal lipid profiles may impact fetal cardiac development. These findings underscore the importance of monitoring lipid levels during pregnancy and suggest potential benefits of managing dyslipidemia to improve fetal cardiac outcomes. However, the study included only a small sample; therefore, the study needs to be continued with a larger group.

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来源期刊
Clinics and Practice
Clinics and Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
4.30%
发文量
91
审稿时长
10 weeks
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