NOTCH1突变对慢性淋巴细胞白血病预后和预测的影响：一项系统综述。

IF 2.2 4区医学 Q3 HEMATOLOGY

Leukemia & Lymphoma Pub Date : 2024-12-27 DOI:10.1080/10428194.2024.2441858

Veronica Guglielmana, Davide Rossi

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引用次数: 0

摘要

NOTCH1癌基因突变常与慢性淋巴细胞白血病（CLL）相关，约10%的慢性淋巴细胞白血病确诊病例中存在NOTCH1癌基因突变。尽管这些突变与临床结果相关，但它们在抗cd20单克隆抗体、布鲁顿酪氨酸激酶抑制剂和BCL2抑制剂治疗中的意义仍存在争议。因此，在临床环境之外不建议检测NOTCH1突变。本系统的文献综述旨在巩固目前对NOTCH1突变的理解，即NOTCH1突变是探索性的，不推荐用于常规临床实践。

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Prognostic and predictive impact of NOTCH1 mutation in chronic lymphocytic leukemia: a systematic review.

Mutations in the NOTCH1 oncogene are recurrently linked to chronic lymphocytic leukemia (CLL), found in approximately 10% of CLL cases at diagnosis. Although these mutations are associated with clinical outcomes, their significance in the context of treatment with anti-CD20 monoclonal antibodies, Bruton's tyrosine kinase inhibitors, and BCL2 inhibitors remains controversial. Consequently, testing for NOTCH1 mutations is not recommended outside of a clinical setting. This systematic literature review aims to consolidate the current understanding that NOTCH1 mutations are exploratory and not recommended for routine clinical practice.

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来源期刊

Leukemia & Lymphoma 医学-血液学

CiteScore

4.10

自引率

3.80%

发文量

384

审稿时长

1.8 months

期刊介绍： Leukemia & Lymphoma in its fourth decade continues to provide an international forum for publication of high quality clinical, translational, and basic science research, and original observations relating to all aspects of hematological malignancies. The scope ranges from clinical and clinico-pathological investigations to fundamental research in disease biology, mechanisms of action of novel agents, development of combination chemotherapy, pharmacology and pharmacogenomics as well as ethics and epidemiology. Submissions of unique clinical observations or confirmatory studies are considered and published as Letters to the Editor