Francisco Gerardo Yanowsky-Escatell, Leonardo Pazarin-Villaseñor, Jorge Andrade-Sierra, Yessica García-Salas, Andrés García Sánchez, Alejandra Guillermina Miranda-Díaz, Tonatiuh Delgado-Figueroa, Pedro Alberto Mendoza-Rosales, Eduardo de Jesús Torres-Vázquez, Carlos Alberto Andrade-Castellanos, María Teresa Tapia de la Paz, Diana Mercedes Hernández-Corona, Tonatiuh González-Heredia, Kevin Javier Arellano-Arteaga, Luis Miguel Róman-Pintos
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This study was an attempt to determine the association between the presence of PEW and OS levels in PD patients.</p><p><strong>Methods: </strong>This analytical cross-sectional study involved 62 clinically stable PD patients aged ≥ 18 years, between September 2017 and July 2018. PEW was assessed using PEW definition criteria, 7-point Subjective Global Assessment (SGA), and Malnutrition-Inflammation Score (MIS). Redox state was evaluated through oxidants (lipoperoxides, 8-Isoprostane, nitric oxide), antioxidants (superoxide dismutase, catalase, glutathione peroxidase-GPx, total antioxidant capacity), and oxidative DNA damage [8-hydroxy2'-deoxyguanosine-8-OHdG, 8-Oxoguanine-DNA-N-Glycosylase-1(8-OHdG)].</p><p><strong>Results: </strong>Among study participants, 38 (61.2%) were males and 24 (38.8%) were females; 22 (35.4%) had diabetes mellitus [males 15 (68.1%) and females 7 (31.8%)]. The average PD duration was 11 (4-27) months, body mass index: 23.5 ± 4.1 kg/m2, energy intake: 1138.4 ± 394.2 kcal/day, and protein intake: 50.2 ± 18.5 g/day. Prevalence of PEW varied based on the assessment method used (50-88.7%). Plasma 8-OHdG levels were higher in patients with PEW evaluated by MIS (0.1 [0.1-56.4] vs. 1.8 [0.1-74.7] ng/mL, P = .028), while GPx activity was lower in the presence of PEW as measured by MIS (3.6 [3.1-7.6] vs. 2.8 [1.2-10] nmol/min/mL, P = .021). 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引用次数: 0
摘要
导读：蛋白能量消耗（PEW）在腹膜透析（PD）患者中非常普遍，氧化应激（OS）可能是其发病机制的一部分。本研究试图确定PD患者中存在的PEW和OS水平之间的关系。方法：本分析性横断面研究纳入62例年龄≥18岁的临床稳定PD患者，时间为2017年9月至2018年7月。使用PEW定义标准、7分主观整体评估（SGA）和营养不良炎症评分（MIS）对PEW进行评估。通过氧化剂（脂过氧化物、8-异前列腺素、一氧化氮）、抗氧化剂（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶gpx、总抗氧化能力）和氧化DNA损伤[8-羟基2'-脱氧鸟苷-8-OHdG， 8-氧鸟苷-DNA- n -糖基化酶-1(8-OHdG)]来评估氧化还原状态。结果：男性38人（61.2%），女性24人（38.8%）；糖尿病22例（35.4%），其中男性15例（68.1%），女性7例（31.8%）。平均PD病程11（4 ~ 27）个月，体重指数23.5±4.1 kg/m2，能量摄入1138.4±394.2 kcal/d，蛋白质摄入50.2±18.5 g/d。PEW的患病率因评估方法的不同而不同（50-88.7%）。MIS检测的皮尤患者血浆8-OHdG水平较高（0.1 [0.1-56.4]vs. 1.8 [0.1-74.7] ng/mL, P = 0.028），而MIS检测的皮尤患者GPx活性较低（3.6 [3.1-7.6]vs. 2.8 [1.2-10] nmol/min/mL, P = 0.021）。在PEW标记物和剩余OS水平之间没有观察到显著差异。结论：在伴有PEW的PD患者中，通过MIS评估，8-OHdG显著升高，而GPx活性显著降低。
Association of Protein Energy Wasting and Oxidative Stress Markers in Peritoneal Dialysis.
Introduction: Protein-energy wasting (PEW) is highly prevalent among patients undergoing peritoneal dialysis (PD), and it has been proposed that oxidative stress (OS) may contribute to its pathogenesis. This study was an attempt to determine the association between the presence of PEW and OS levels in PD patients.
Methods: This analytical cross-sectional study involved 62 clinically stable PD patients aged ≥ 18 years, between September 2017 and July 2018. PEW was assessed using PEW definition criteria, 7-point Subjective Global Assessment (SGA), and Malnutrition-Inflammation Score (MIS). Redox state was evaluated through oxidants (lipoperoxides, 8-Isoprostane, nitric oxide), antioxidants (superoxide dismutase, catalase, glutathione peroxidase-GPx, total antioxidant capacity), and oxidative DNA damage [8-hydroxy2'-deoxyguanosine-8-OHdG, 8-Oxoguanine-DNA-N-Glycosylase-1(8-OHdG)].
Results: Among study participants, 38 (61.2%) were males and 24 (38.8%) were females; 22 (35.4%) had diabetes mellitus [males 15 (68.1%) and females 7 (31.8%)]. The average PD duration was 11 (4-27) months, body mass index: 23.5 ± 4.1 kg/m2, energy intake: 1138.4 ± 394.2 kcal/day, and protein intake: 50.2 ± 18.5 g/day. Prevalence of PEW varied based on the assessment method used (50-88.7%). Plasma 8-OHdG levels were higher in patients with PEW evaluated by MIS (0.1 [0.1-56.4] vs. 1.8 [0.1-74.7] ng/mL, P = .028), while GPx activity was lower in the presence of PEW as measured by MIS (3.6 [3.1-7.6] vs. 2.8 [1.2-10] nmol/min/mL, P = .021). No significant differences were observed between PEW markers and remaining OS levels.
Conclusions: In PD patients with PEW, assessed by MIS, 8-OHdG was significantly increased, while GPx activity was significantly low.
期刊介绍：
The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.
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