心脏迷走神经控制和炎症在异常长寿的人类中被上调。

IF 3.2 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Internal and Emergency Medicine Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI:10.1007/s11739-024-03837-8

Gabriel Dias Rodrigues, Domenico Azzolino, Valentina Manzini, Marco Proietti, Angelica Carandina, Costanza Scatà, Chiara Bellocchi, Eleonora Tobaldini, Evelyn Ferri, Beatrice Arosio, Matteo Cesari, Nicola Montano

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引用次数: 0

摘要

我们研究了极端长寿者（PEL）、他们的直系后代（DO）和一组年龄和性别与极端长寿者相匹配的对照组中心血管自主神经和炎症谱的相互作用。通过心率变异性（HRV）评估心脏自主控制，采用光谱和符号分析。测定血浆中白细胞介素(IL)-10、IL-6、TNF-α的浓度及基因表达。在PEL中，交感迷走神经转向迷走神经优势，与DO和对照组相比，促炎性和抗炎性循环细胞因子均增加。同样，在DO和对照组之间没有发现HRV差异。这些初步结果表明，至少在我们的小样本中，环境因素可能克服遗传对心脏自主控制和炎症循环细胞因子的影响。

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Cardiac vagal control and inflammation are upregulated in exceptional human longevity.

We investigated the interplay of cardiovascular autonomic and inflammatory profiles in persons with extreme longevity (PEL), their direct offsprings (DO), and a group of controls matched for age and sex with the DO. Cardiac autonomic control was assessed through the heart rate variability (HRV) using spectral and symbolic analysis. The plasma concentration and gene expression of interleukin (IL)-10, IL-6, and TNF-α were quantified. In PEL, the sympatho-vagal is shifted to a vagal predominance and both pro- and anti-inflammatory circulation cytokines are increased compared to DO and controls. Also, no differences were found in HRV between DO and controls. These preliminary results suggest that environmental factors, at least in our small sample, may overcome the impact of heritability on cardiac autonomic control and inflammatory circulation cytokines.

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来源期刊

Internal and Emergency Medicine 医学-医学：内科

CiteScore

7.20

自引率

4.30%

发文量

258

审稿时长

6-12 weeks

期刊介绍： Internal and Emergency Medicine (IEM) is an independent, international, English-language, peer-reviewed journal designed for internists and emergency physicians. IEM publishes a variety of manuscript types including Original investigations, Review articles, Letters to the Editor, Editorials and Commentaries. Occasionally IEM accepts unsolicited Reviews, Commentaries or Editorials. The journal is divided into three sections, i.e., Internal Medicine, Emergency Medicine and Clinical Evidence and Health Technology Assessment, with three separate editorial boards. In the Internal Medicine section, invited Case records and Physical examinations, devoted to underlining the role of a clinical approach in selected clinical cases, are also published. The Emergency Medicine section will include a Morbidity and Mortality Report and an Airway Forum concerning the management of difficult airway problems. As far as Critical Care is becoming an integral part of Emergency Medicine, a new sub-section will report the literature that concerns the interface not only for the care of the critical patient in the Emergency Department, but also in the Intensive Care Unit. Finally, in the Clinical Evidence and Health Technology Assessment section brief discussions of topics of evidence-based medicine (Cochrane’s corner) and Research updates are published. IEM encourages letters of rebuttal and criticism of published articles. Topics of interest include all subjects that relate to the science and practice of Internal and Emergency Medicine.