免疫衰老和与年龄有关的免疫细胞：与年龄有关的疾病的原因。

IF 6.9 3区医学 Q1 CHEMISTRY, MEDICINAL

Archives of Pharmacal Research Pub Date : 2024-12-26 DOI:10.1007/s12272-024-01529-7

Nam-Hee Kim, So-Jin Sim, Hong-Gyu Han, Jeong-Hyuk Yoon, Yong-Hyun Han

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引用次数: 0

摘要

免疫衰老是由于衰老导致的免疫系统的减弱，其特征是免疫细胞的变化和免疫功能的失调。与年龄相关的免疫细胞随着年龄的增长而增加。它们与慢性长期炎症有关，引起组织功能障碍和与年龄有关的疾病。在这里，我们讨论了衰老巨噬细胞促炎活性的增加，具有年龄相关表型的淋巴细胞的积累，以及这些免疫细胞功能和特征的特异性改变。这些细胞变化与年龄相关疾病的发展有关。此外，我们回顾了针对年龄相关免疫衰老的各种治疗策略，为减轻年龄相关疾病的影响提供了途径。

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Immunosenescence and age-related immune cells: causes of age-related diseases.

Immunosenescence is a weakening of the immune system due to aging, characterized by changes in immune cells and dysregulated immune function. Age-related immune cells are increasing with aging. They are associated with chronic prolonged inflammation, causing tissue dysfunction and age-related diseases. Here, we discuss increased pro-inflammatory activity of aged macrophages, accumulation of lymphocytes with an age-associated phenotype, and specific alterations in both functions and characteristics of these immune cells. These cellular changes are associated with development of age-related diseases. Additionally, we reviewed various therapeutic strategies targeting age-related immunosenescence, providing pathways to mitigate effects of age-related diseases.

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.