人参皂苷Rg3抑制肝纤维化作用的分子机制研究进展。

IF 4.8 2区 医学 Q1 TOXICOLOGY
Zhao-feng Tian, Rui-yi Hu, Zi Wang, Ya-jun Wang, Wei Li
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引用次数: 0

摘要

肝炎是一种慢性炎症性肝病,是肝纤维化的重要原因,如果不及时治疗,可发展为肝硬化甚至肝细胞癌。但肝纤维化是一种可逆性疾病,寻找新的干预靶点和分子标志物是防治肝纤维化的关键。人参是一种珍贵的中药,具有很高的药用价值,被誉为“万草之王”,其有效成分人参皂苷Rg3是一种罕见的皂苷类新药,是大量研究中研究最彻底、最广泛的药物之一。人参皂苷Rg3是从人参中提取的一种活性成分,具有多种生物活性,包括抗炎、抗氧化和抗纤维化作用。几项研究表明,人参皂苷Rg3可能有助于减轻肝脏炎症和氧化应激,从而减缓肝纤维化的进展。人参皂苷Rg3可能对肝纤维化具有一定的治疗作用,其作用机制可能与细胞自噬、细胞凋亡、抗炎症以及抗氧化活性和多种信号通路的调节有关。综述了人参皂苷Rg3抑制肝纤维化作用的分子机制,以期为相关研究提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular mechanisms behind the inhibitory effects of ginsenoside Rg3 on hepatic fibrosis: a review

Hepatitis is a chronic inflammatory liver disease and an important cause of liver fibrosis, which can progress to cirrhosis and even hepatocellular carcinoma if left untreated. However, liver fibrosis is a reversible disease, so finding new intervention targets and molecular markers is the key to preventing and treating liver fibrosis. Ginseng, the roots of Panax ginseng C. A. Meyer, is a precious Traditional Chinese Medicines with high medicinal value and is known as the “king of all herbs”, and its active ingredient, ginsenoside Rg3 is a rare saponin and a new class of drug, one of the most thoroughly and extensively studied in a large number of studies. Ginsenoside Rg3 is an active ingredient extracted from ginseng that possesses a variety of biological activities, including anti-inflammatory, antioxidant, and anti-fibrotic effects. Several studies have suggested that ginsenoside Rg3 may help reduce hepatic inflammation and oxidative stress, thereby slowing the progression of liver fibrosis. Ginsenoside Rg3 may have some therapeutic effects on liver fibrosis, and the underlying molecular mechanisms behind these effects are attributed to cellular autophagy, apoptosis, and anti-inflammation, as well as the modulation of antioxidant activity and multiple signaling pathways. The molecular mechanisms behind the inhibitory effect of ginsenoside Rg3 on hepatic fibrosis are reviewed, with a view to providing reference for related studies.

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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
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