LiF TLD-100在碳离子束中的表征。

IF 3.2 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Medical physics Pub Date : 2024-12-24 DOI:10.1002/mp.17605
Paige A. Taylor, Alfredo Mirandola, Mario Ciocca, Shannon Hartzell, Giuseppe Magro, Paola Alvarez, Christine B. Peterson, Christopher R. Peeler, Eugene J. Koay, Rebecca M. Howell, Stephen F. Kry
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引用次数: 0

摘要

背景:用于测量碳离子束剂量的被动剂量计框架尚未被表征或实现常规使用。目的:确定治疗用碳离子束热释光剂量计吸收剂量的剂量计算校正因子。TLD可能是远程审计的有用工具,特别是在临床试验的背景下,因为碳离子放射治疗的新方案正在开发。方法:在意大利帕维亚国家肿瘤中心(CNAO)用碳离子束辐照TLD-100。对线性、衰落和光束质量的剂量校正因子进行了表征。在辐照后5 ~ 100天发生褪色。为了达到线性,在高能量原始碳离子峰入口和2 cm展开布拉格峰中心,对tld进行了1 ~ 15 Gy的吸收剂量照射。为了提高光束质量,在几个原始碳离子布拉格峰以及几个扩展布拉格峰中,TLD被照射到相同的吸收剂量(3 Gy)。计算各校正因子,并与光子校正因子进行比较。并比较了碳离子束中高、低剂量平均线性能量传递(LETD)的校正因子。应用碳离子TLD校正因子,比较离子室与TLD-100在几种组织替代体模材料中的吸收剂量。结果:光子、低LETD碳离子束和高LETD碳离子束的TLD衰落校正因子差异无统计学意义。在光子、低LETD碳离子和高LETD碳离子之间,TLD线性校正因子存在差异。光束质量校正系数较大,且随LETD呈线性变化。在1 σ水平下,碳离子吸收剂量计算的总体不确定度为3.9%,主要是由于光束质量校正的不确定度为3.5%。在聚乙烯、固体水(Gammex和Sun Nuclear)、丙烯酸、蓝水和techtron HPV的幻影材料中,TLD测量值与离子室测量值的误差在1.2%以内。与离子室相比,轻木的TLD测量值在3.0%以内,软木的TLD测量值低6.6%。结论:TLD-100可用于治疗性碳离子束的被动剂量测定。重要的是,线性度和光束质量校正因子都不同于光子治疗,并且依赖于碳离子束的LETD。这开启了TLD用于碳离子输出审计、幻像审计和体内剂量测量的可能性,但可能会受到更复杂的管理和比在光子光束中实现的更大的不确定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Characterization of LiF TLD-100 in carbon ion beams for remote audits

Background

A passive dosimeter framework for the measurement of dose in carbon ion beams has yet to be characterized or implemented for regular use.

Purpose

This work determined the dose calculation correction factors for absorbed dose in thermoluminescent dosimeters (TLDs) in a therapeutic carbon ion beam. TLD could be a useful tool for remote audits, particularly in the context of clinical trials as new protocols are developed for carbon ion radiotherapy.

Methods

TLD-100 were irradiated in a carbon ion beam at the Centro Nazionale di Adroterapia Oncologica (CNAO) in Pavia, Italy. The dose correction factors for linearity, fading, and beam quality were characterized. Fading was characterized from 5 to 100 days post-irradiation. For linearity, the TLDs were irradiated to absorbed doses ranging from 1 to 15 Gy in both the entrance of a high-energy pristine carbon ion peak and the center of a 2 cm spread-out Bragg peak. For beam quality, the TLD was irradiated to the same absorbed dose (3 Gy) in several pristine carbon ion Bragg peaks, as well as in several spread-out Bragg peaks. Each correction factor was calculated and compared to photon correction factors. The correction factors were also compared between high and low dose-averaged linear energy transfer (LETD) in the carbon ion beams. The absorbed dose was compared between ion chamber and TLD-100 in the several tissue substitute phantom materials, applying the carbon ion TLD correction factors.

Results

There was no statistically significant difference in the TLD fading correction factor between photons, low LETD carbon ion beams, or high LETD carbon ion beams. The TLD linearity correction factor did differ between photons, low LETD carbon ions, and high LETD carbon ions. The beam quality correction factor was large and changed linearly with LETD. The overall uncertainty of the carbon ion absorbed dose calculation was 3.9% at the one-sigma level, driven largely by a 3.5% uncertainty in the beam quality correction. TLD measurements were within 1.2% of ion chamber measurements in the phantom material for polyethylene, solid water (Gammex and Sun Nuclear), acrylic, blue water, and techtron HPV. TLD measurements in balsa wood were within 3.0% and cork was 6.6% low compared to ion chamber.

Conclusion

TLD-100 can be used for passive dosimetry in a therapeutic carbon ion beam. Importantly, the linearity and beam quality correction factors are both different from photon therapy, and dependent on LETD of the carbon ion beam. This opens the possibility of TLD use for carbon ion output audits, phantom audits, and in vivo dose measurements, but may be subject to more complicated management and slightly larger uncertainties than are achieved in photon beams.

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来源期刊
Medical physics
Medical physics 医学-核医学
CiteScore
6.80
自引率
15.80%
发文量
660
审稿时长
1.7 months
期刊介绍: Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.
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