Lija James, Louise H Hailey, Rhea Suribhatla, Dylan McGagh, Raj Amarnani, Christine E Bundy, Shona Kirtley, Denis O'Sullivan, Ingrid Steinkoenig, Jonathan P E White, Arani Vivekanantham, Laura C Coates
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Patients may experience a range of physical and psychological issues.</p><p><strong>Objective: </strong>To examine the impact of PsA on an individual's quality of life (QoL) and physical function.</p><p><strong>Design: </strong>A systematic review of the literature.</p><p><strong>Data sources and methods: </strong>A comprehensive search was conducted across seven electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, AMED, EMBASE, Global Health, MEDLINE and PsycINFO) to retrieve articles related to QoL and lifestyle in adults with PsA. The inclusion criteria were studies published between 2010 and 2021 that used outcomes validated in patients with PsA. The methodological quality was assessed using Joanna Briggs Institute Critical Appraisal Tools. Our primary outcomes were patient-reported outcomes (PROs) measuring QoL and the impact of disease on physical function. The secondary outcomes were assessments of fatigue, anxiety, depression, sleep, work productivity and employment.</p><p><strong>Results: </strong>The study included 37 comprehensive studies that examined the impact of PsA on QoL and physical function. The findings revealed that the impact of PsA extends to various aspects of life, including activities of daily living, physical, and emotional aspects, such as fatigue, sleep disturbance, anxiety and depression. Notably, people with PsA experience reduced health-related quality of life (HRQoL), particularly in emotional, social and mental health aspects. The severity of pain and/or fatigue is directly linked to decreased HRQoL. Importantly, those who fail to achieve minimal disease activity face challenges in work productivity and employment status.</p><p><strong>Conclusion: </strong>To conclude, our review underscores the significant impact of PsA on patients' HRQoL beyond joint disease. 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引用次数: 0
摘要
背景：银屑病关节炎（PsA）是一种慢性炎症，可影响所有年龄的个体。患者可能会经历一系列的生理和心理问题。目的：探讨前列腺特异性抗原（PsA）对个体生活质量（QoL）和身体功能的影响。设计：对文献进行系统回顾。数据来源和方法：通过7个电子数据库（Cochrane Central Register of Controlled Trials, Central）、CINAHL、AMED、EMBASE、Global Health、MEDLINE和PsycINFO)进行全面检索，检索与成人PsA患者的生活质量和生活方式相关的文章。纳入标准是2010年至2021年间发表的研究，使用PsA患者验证的结果。方法质量使用乔安娜布里格斯研究所关键评估工具进行评估。我们的主要结局是衡量生活质量的患者报告结局（pro）和疾病对身体功能的影响。次要结果是对疲劳、焦虑、抑郁、睡眠、工作效率和就业的评估。结果：该研究包括37项综合研究，研究了PsA对生活质量和身体功能的影响。研究结果表明，PsA的影响延伸到生活的各个方面，包括日常生活活动、身体和情绪方面，如疲劳、睡眠障碍、焦虑和抑郁。值得注意的是，PsA患者的健康相关生活质量（HRQoL）下降，尤其是在情感、社会和心理健康方面。疼痛和/或疲劳的严重程度与HRQoL的下降直接相关。重要的是，那些未能实现最低疾病活动的人在工作生产率和就业状况方面面临挑战。结论：总之，我们的综述强调了PsA对患者HRQoL的显著影响，而不仅仅是关节疾病。PsA的情感、社会和心理方面需要富有同情心和全面的管理。试验注册：PROSPERO国际前瞻性系统评价注册- CRD42021257395。
The impact of psoriatic arthritis on quality of life: a systematic review.
Background: Psoriatic arthritis (PsA) is a chronic inflammatory condition that can affect individuals of all ages. Patients may experience a range of physical and psychological issues.
Objective: To examine the impact of PsA on an individual's quality of life (QoL) and physical function.
Design: A systematic review of the literature.
Data sources and methods: A comprehensive search was conducted across seven electronic databases (Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL, AMED, EMBASE, Global Health, MEDLINE and PsycINFO) to retrieve articles related to QoL and lifestyle in adults with PsA. The inclusion criteria were studies published between 2010 and 2021 that used outcomes validated in patients with PsA. The methodological quality was assessed using Joanna Briggs Institute Critical Appraisal Tools. Our primary outcomes were patient-reported outcomes (PROs) measuring QoL and the impact of disease on physical function. The secondary outcomes were assessments of fatigue, anxiety, depression, sleep, work productivity and employment.
Results: The study included 37 comprehensive studies that examined the impact of PsA on QoL and physical function. The findings revealed that the impact of PsA extends to various aspects of life, including activities of daily living, physical, and emotional aspects, such as fatigue, sleep disturbance, anxiety and depression. Notably, people with PsA experience reduced health-related quality of life (HRQoL), particularly in emotional, social and mental health aspects. The severity of pain and/or fatigue is directly linked to decreased HRQoL. Importantly, those who fail to achieve minimal disease activity face challenges in work productivity and employment status.
Conclusion: To conclude, our review underscores the significant impact of PsA on patients' HRQoL beyond joint disease. The emotional, social, and mental aspects of PsA require compassionate and holistic management.
Trial registration: The PROSPERO international prospective register of systematic reviews - CRD42021257395.
期刊介绍：
Therapeutic Advances in Musculoskeletal Disease delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of musculoskeletal disease.
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