血清血管生成素样4水平对新生儿呼吸窘迫综合征的诊断及预后价值。

IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY

Annals of Clinical Biochemistry Pub Date : 2025-01-12 DOI:10.1177/00045632241312634

Xiuyun Song

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引用次数: 0

摘要

目的：新生儿呼吸窘迫综合征（NRDS）是早产儿最常见的呼吸系统疾病。报道了血管生成素样4 （ANGPTL4）在肺部疾病中的意义。我们深入探讨了血清ANGPTL4在NRDS诊断/预后中的作用。方法：前瞻性选择256例新生儿，其中NRDS患儿128例，非NRDS患儿128例。NRDS婴儿被分为生存组和死亡组。采用ELISA法和受试者工作特征曲线分别评价pi中ANGPTL4水平及其对NRDS的诊断和预后价值。采用多因素logistic回归分析NRDS婴儿死亡的独立危险因素（irf）。结果：NRDS婴儿表现出胎龄、出生体重和5分钟Apgar评分降低。NRDS患儿ANGPTL4水平升高，且随NRDS严重程度升高。NRDS患儿血清ANGPTL4水平与5 min Apgar评分呈负相关。血清ANGPTL4诊断NRDS的曲线下面积为0.902，敏感性为88.28%，特异性为86.72%，临界值为255.98 ng/mL；诊断重度NRDS的AUC为0.741，敏感性66.67%，特异性79.52%，临界值为625.5 ng/mL。低胎龄、出生体重和5分钟Apgar评分、严重NRDS和血清ANGPTL4水平升高是NRDS婴儿死亡的irf。血清ANGPTL4水平升高的NRDS患儿生存率下降，生存时间短。结论：ANGPTL4对NRDS具有较高的诊断价值和死亡预测价值，可作为NRDS诊断和预后的生物标志物。

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The diagnostic and prognostic value of serum angiopoietin-like 4 level in neonatal respiratory distress syndrome.

Objectives: Neonatal respiratory distress syndrome (NRDS) is the most common respiratory disease in preterm infants (PIs). The implication of Angiopoietin-like 4 (ANGPTL4) was reported in lung diseases. We delved into the role of serum ANGPTL4 in NRDS diagnosis/prognosis.

Methods: Totally 256 PIs were prospectively selected, including 128 NRDS infants and 128 non-NRDS PIs. NRDS infants were assigned into Survival and Death groups. ANGPTL4 level in PIs and its diagnostic and prognostic value for NRDS were separately assessed by ELISA and receiver operating characteristic curve. The independent risk factors (IRFs) for death in NRDS infants were analysed by multivariate logistic regression.

Results: NRDS infants exhibited reduced gestational age, birth weight, and 5 min Apgar score. ANGPTL4 level rose in NRDS infants, and increased with NRDS severity. Serum ANGPTL4 level was negatively correlated with 5 min Apgar score in NRDS infants. The area under the curve of serum ANGPTL4 for the diagnosis of NRDS was 0.902, with 88.28% sensitivity, 86.72% specificity, and 255.98 ng/mL cut-off value; the AUC for the diagnosis of severe NRDS was 0.741, with 66.67% sensitivity, 79.52% specificity, and 625.5 ng/mL cut-off value. Low gestational age, birth weight and 5 min Apgar score, severe NRDS, and elevated serum ANGPTL4 levels were IRFs for death in NRDS infants. NRDS infants with increased serum ANGPTL4 level displayed decreased survival rate and short survival time.

Conclusions: ANGPTL4 exhibited high diagnostic value and predictive value for death in NRDS, and it served as a biomarker for the diagnosis and prognosis of NRDS.

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).