通过单电子转移/自由基加成/基团转移接力过程实现钴催化1 -芳基-1,3-二烯的区域选择性重氮化

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-01-08 DOI:10.1039/d4qo02180k

Chi-Fan Zhu , Jun-Ju Mai , Xiao-Jing Li , Mingyuan Shi , Xiasen Dong , Huinan Fu , Mei-Hua Shen , Hua-Dong Xu

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引用次数: 0

摘要

报道了以TMSN3为叠氮化物源，钴催化1 -芳基-1,3-二烯的1,2-二氮化反应。在温和的条件下，合成了一系列含有可进一步功能化的不饱和键的邻二叠氮化合物，具有良好的区域选择性和立体选择性。初步机理研究表明，该反应是通过单电子转移/自由基加成/基团转移接力过程进行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cobalt-catalyzed regioselective diazidation of 1-aryl-1,3-dienes enabled by a single electron transfer/radical addition/group transfer relay process†

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Cobalt-catalyzed regioselective diazidation of 1-aryl-1,3-dienes enabled by a single electron transfer/radical addition/group transfer relay process†

A novel cobalt-catalyzed 1,2-diazidation of 1-aryl-1,3-dienes by using TMSN₃ as an azide source has been reported. A series of vicinal diazides containing unsaturated bonds that are amenable to further functionalization were synthesised with excellent regioselectivity and stereoselectivity under mild conditions. Preliminary mechanistic studies suggest that the reaction proceeds via a single electron transfer/radical addition/group transfer relay process.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量