[功能相关且广泛表达的长链非编码rna的修订]。

Q3 Medicine
D Konina, M Skoblov
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引用次数: 0

摘要

长链非编码rna (lncRNAs)参与了许多细胞过程,同时表现出高度的组织特异性。相比之下,蛋白质编码基因,包括管家基因,表现出广泛的表达模式。本研究的目的是强调广泛表达的lncrna的功能重要性。我们分析了人类细胞中lncRNA位点的细胞生长筛选实验数据,这使我们能够识别18个lncRNA命中。值得注意的是,这些lncrna不仅在大多数人体组织中广泛表达,而且在其中发挥功能作用。详细研究表明,它们包含多种分子功能,从心肌细胞损伤控制到巨噬细胞类别转换。有趣的是,实验数据强调了这样一个事实,即这些lncrna的很大一部分编码小但功能多肽。鉴定出了NEAT1、SNHG1、SNHG7、SNHG12、SNHG15、SNHG16、MIR17HG、LINC00680、LINC00263和LINC00339这组极有可能被翻译成小多肽的lncRNAs。此外,对于EPB41L4A-AS1、CRNDE、SNHG6、LINC00493和LINC01420,建立了与RNA序列和它们编码的小蛋白相关的双重功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Revision of Functionally Relevant and Widely Expressed Long Non-Coding RNAs].

Long non-coding RNAs (lncRNAs) are involved in many cellular processes while displaying high tissue specificity. In contrast, protein-coding genes, including the category of housekeeping ones, exhibit broad expression patterns. The aim of this study was to highlight the functional importance of widely expressed lncRNAs. We analyzed experimental data from cell-growth screen of lncRNA loci in human cells, which allowed us to identify 18 lncRNA hits. Notably, these lncRNAs were not only widely expressed in most human tissues, but also played functional roles within them. Detail investigation revealed them encompass a variety of molecular functions, from cardiomyocyte damage controlling to macrophage class switching. Interestingly, experimental data highlighted the fact that a significant part of these lncRNAs encoded small but functional polypeptides. A set of lncRNAs, NEAT1, SNHG1, SNHG7, SNHG12, SNHG15, SNHG16, MIR17HG, LINC00680, LINC00263 and LINC00339, that were highly likely to be translated into small polypeptides was identified. Additionally, for EPB41L4A-AS1, CRNDE, SNHG6, LINC00493, and LINC01420, a dual function associated with both the RNA sequences and small proteins they encoded was established.

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来源期刊
Molekulyarnaya Biologiya
Molekulyarnaya Biologiya Medicine-Medicine (all)
CiteScore
0.70
自引率
0.00%
发文量
131
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