免疫检查点B7-H3是前列腺癌的潜在治疗靶点。

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Discover. Oncology Pub Date : 2024-12-22 DOI:10.1007/s12672-024-01674-x

Qi Shen, Kaichen Zhou, Haosen Lu, Jielin Zhang, Qiqing Xu, Chengsi Zhang, Chunhua Yang, Lijun Mao

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引用次数: 0

摘要

免疫检查点分子B7-H3 （CD276）在许多癌症类型中的高表达使其成为一个有前途的免疫治疗靶点。B7-H3在肿瘤中的共抑制和共刺激作用已被证实，但双重作用下B7-H3免疫应答的机制尚不清楚。B7-H3在前列腺癌的迁移侵袭、血管生成、代谢和化疗耐药等过程中起着至关重要的作用。除了对肿瘤环境的潜在免疫作用外，B7-H3在肿瘤进展中起非免疫介导的作用。本文就B7-H3在前列腺癌中的分子机制进行综述，并讨论B7-H3作为前列腺癌治疗新靶点的潜力。

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Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer.

High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic target. Both coinhibitory and costimulatory effects of B7-H3 in tumors have been demonstrated, but the mechanism of B7-H3 immune response under dual effects is open to question. B7-H3 is crucially involved in the migration and invasion, angiogenesis, metabolism and chemotherapy resistance of prostate cancer. In addition to the potential immune effects on tumor environment, B7-H3 plays a non-immune-mediated role in tumor progression. In this review, we summarize current understanding of molecular mechanism of B7-H3 in prostate cancer and discuss the potential of B7-H3 as a novel therapeutic target for prostate cancer.

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